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Children were evaluated by weight\/height determinations, anthropomorphic measurements, and laboratory studies. TPN was associated with an improved nutritional status during therapy as compared with control patients on ad libitum intake. However, when TPN was discontinued, weight declined and there were no differences among treated and control patients detected at three\u2010month follow\u2010up. Likewise there was no obvious effect from TPN on tolerance to therapy in the adequately nourished child. TPN as initial supportive therapy should be reserved for those children who are malnourished or marginally malnourished at the time of presentation. Close nutritional assessment during treatment is essential since approximately 25% of children undergoing abdominal\/pelvic radiotherapy with chemotherapy can be expected to become malnourished during an initial course of therapy.<\/jats:p>","DOI":"10.1002\/mpo.2950100203","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T15:21:54Z","timestamp":1171984914000},"page":"129-139","source":"Crossref","is-referenced-by-count":51,"title":["A prospective randomized clinical trial of total parenteral nutrition in children with cancer"],"prefix":"10.1002","volume":"10","author":[{"given":"Sarah S.","family":"Donaldson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret 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