{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T03:10:26Z","timestamp":1699845026844},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":8966,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[1982,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 4\u2010year\u2010old girl presenting with vomiting, abdominal pain, and renal failure was found to have gross hepatosplenomegaly, a renal mass, and bilateral pleural effusions. A diagnosis of acute lymphoblastic leukaemia (ALL) was suggested by a peripheral white cell count (WCC) of 119,000 \u00d7 10<jats:sup>6<\/jats:sup>\/mm<jats:sup>3<\/jats:sup>, 57% blasts, 22% lymphocytes, and confirmed by bone marrow examination. Lymphocyte surface marker studies at diagnosis enabled classification as a T\u2010ALL, with a significant proportion of the T cells also bearing receptors for the third component of complement (C3). Seventy\u2010two percent of the peripheral blood mononuclear cells reacted with anti\u2010Ia monoclonal antibody (FMC 4), and a smaller proportion (25%) carried receptors for the Fc portion of IgG.<\/jats:p><jats:p>The T\u2010classification of this ALL was verified at central nervous system (CNS) relapse and at a subsequent nodal relapse. Double\u2010marker studies on cells from the infiltrated lymph node prepared in suspension confirmed the presence of Ia\u2010positive T cells. The Ia marker is usually a useful discriminant between T and non\u2010T cells in normal and ALL cell populations. The case described here highlights the need for a panel of markers to be used in classification of childhood ALL and supports the suggestion that there is a distinct subtype of Ia\u2010positive T\u2010ALL.<\/jats:p>","DOI":"10.1002\/mpo.2950100406","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T15:20:03Z","timestamp":1171984803000},"page":"359-367","source":"Crossref","is-referenced-by-count":1,"title":["Childhood T\u2010cell acute lymphoblastic leukaemia expressing \u201cIa\u2010like\u201d antigen: A case report"],"prefix":"10.1002","volume":"10","author":[{"given":"Ann","family":"Kupa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian G. 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