{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T06:56:00Z","timestamp":1777359360676,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2008,4,16]],"date-time":"2008-04-16T00:00:00Z","timestamp":1208304000000},"content-version":"vor","delay-in-days":9602,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[1982,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Granulocyte rich buffy coats were transfused to infected neutropenic patients when leukapheresis donors were not available. Efficacy of transfusions was evaluated from data supplied by hospitals administering them. Buffy coats separated from ACD blood contained a mean of 4.9 \u00d7 10<jats:sup>8<\/jats:sup> granulocytes. Fifty\u2010seven patients received a course consisting of a mean of 3.8 transfusions. Of these, 27 received a mean of 17.5 units per transfusion and had a survival rate of 44.4%, which was not significantly different from the 50.0% found in 30 who received a mean of 11.1 units per transfusion. No significant difference in survival rate was found between 31 patients with acute leukemia and 26 with other disorders or 38 patients with positive and 19 with negative cultures. Finally, no significant difference in survival rate was noted between patients who received a course of \u226b four transfusions or \u226a three transfusions in any of the above groups. Survival rates were less than those generally reported following similar courses of leukapheresis units. Buffy coat transfusions consisting of a mean of approximately 17.5 units as produced during this study have therefore been shown to be not generally beneficial. The increased survival seen in some studies utilizing leukapheresis products may relate in part to the larger number of granulocytes they contained. Greater benefit from buffy coat transfusions might result if the number of granulocytes infused were increased. Evaluation of possible efficacy associated with transfusions of increased numbers of buffy coat units further enriched with granulocytes may be justified when leukapheresis donors are not available.<\/jats:p>","DOI":"10.1002\/mpo.2950100504","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T15:19:59Z","timestamp":1171984799000},"page":"447-454","source":"Crossref","is-referenced-by-count":7,"title":["Transfusion of granulocyte rich buffy coats to neutropenic patients"],"prefix":"10.1002","volume":"10","author":[{"given":"R. F.","family":"Reiss","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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Vox Sang"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950060110"},{"key":"e_1_2_1_8_2","first-page":"384","article-title":"Human blood components I","volume":"20","author":"Waldman AA","year":"1980","journal-title":"Preparation and characteristics of leukocyte concentrates from single units of whole blood. Transfusion"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(78)90753-2"},{"key":"e_1_2_1_10_2","unstructured":"KotwasL:Pheresis donor reactions and complications: Prevention recognition and management. In: \u201cFundamentals of the Pheresis Program.\u201d Washington DC: American Association of Blood Banks 1979 p.63."},{"key":"e_1_2_1_11_2","unstructured":"NusbacherJ: Controlling the leukapheresis process. 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Joint Meeting of the 18th Congress of the International Society of Hematology and the 16th Congress of the International Society of Blood Transfusion Montreal Canada 1980."},{"key":"e_1_2_1_24_2","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1182\/blood.V59.2.328.328","article-title":"Experimental candidiasis in neutropenic dogs: Tissue burden of infection and granulocyte transfusion effects","volume":"59","author":"Chow HS","year":"1982","journal-title":"Blood"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V54.4.766.766"},{"key":"e_1_2_1_26_2","first-page":"399","article-title":"A new method for the collection of human granulocytes by gravity sedimentation","volume":"18","author":"Djerassi I","year":"1977","journal-title":"Proc Am Soc Clin Oncol"}],"container-title":["Medical and Pediatric Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmpo.2950100504","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mpo.2950100504","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T02:39:38Z","timestamp":1699843178000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mpo.2950100504"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,1]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1982,1]]}},"alternative-id":["10.1002\/mpo.2950100504"],"URL":"https:\/\/doi.org\/10.1002\/mpo.2950100504","archive":["Portico"],"relation":{},"ISSN":["0098-1532","1096-911X"],"issn-type":[{"value":"0098-1532","type":"print"},{"value":"1096-911X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1982,1]]}}}