{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:54:36Z","timestamp":1760853276870},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":8601,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[1983,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Twenty\u2010eight patients with histiocytosis \u00d7 (HX) who had bone marrow aspirates and\/or trephine biopsies taken at diagnosis were studied. Five of the 28 patients (18%) had bone marrow specimens with clusters of benign histiocytes characteristic of histiocytosis X. Several statistically significant clinical and laboratory differences were found between those patients with postive marrows versus those with uninvolved bone marrows. Presence of HX in the bone marrow was more frequently associated with fever (P &lt; 0.01), splenomegaly (P &lt; 0.01), rash (P = 0.04), diabetes insipidus (P = 0.09), and platelet counts less than 175 \u00d7 10<jats:sup>9<\/jats:sup>\/L (P = 0.01). Two of the five patients with bone marrow involvement died, whereas there were no deaths due to HX in the other 23 patients. From this review, it is suggested that bone marrow involvement at diagnosis may be associated with more extensive and potentially fatal disease. HX of the marrow was more easily diagnosed from trephine biopsy sections than aspiration smears.<\/jats:p>","DOI":"10.1002\/mpo.2950110307","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T15:44:11Z","timestamp":1171986251000},"page":"167-171","source":"Crossref","is-referenced-by-count":30,"title":["Bone marrow involvement in histiocytosis X"],"prefix":"10.1002","volume":"11","author":[{"given":"K.","family":"McClain","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. K. C.","family":"Ramsay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Robison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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Integration of eosinophilic granuloma of the bone, \u201cLetterer\u2010Siwe disease\u201d and Schuller\u2010Christian disease as related manifestations of a single nosologic entity","volume":"56","author":"Lichtenstein R","year":"1953","journal-title":"Arch Pathol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-196909000-00002"},{"key":"e_1_2_1_12_2","first-page":"251","volume-title":"Perspectives in Pediatric Pathology","author":"Newton WA","year":"1973"},{"key":"e_1_2_1_13_2","first-page":"219","volume-title":"Granulomatous reticuloendotheliosis, with emphasis on diagnosis from dry film material. Proceedings of the International Society of Hematology, VI Congress. 160, (Abstract)","author":"Sundberg RD","year":"1956"},{"key":"e_1_2_1_14_2","first-page":"1845","article-title":"Thrombocytosis in histiocytosis\u2010X","volume":"79","author":"Kamalakon P","year":"1979","journal-title":"NY State Med J"},{"key":"e_1_2_1_15_2","first-page":"193","volume-title":"Cancer in Children, Clinical Management","author":"Nesbit ME","year":"1973"},{"key":"e_1_2_1_16_2","first-page":"153","volume-title":"Perspectives in Pediatric Pathology","author":"Nezelof C","year":"1979"}],"container-title":["Medical and Pediatric Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmpo.2950110307","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mpo.2950110307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T03:14:04Z","timestamp":1697771644000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mpo.2950110307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,1]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1983,1]]}},"alternative-id":["10.1002\/mpo.2950110307"],"URL":"https:\/\/doi.org\/10.1002\/mpo.2950110307","archive":["Portico"],"relation":{},"ISSN":["0098-1532","1096-911X"],"issn-type":[{"value":"0098-1532","type":"print"},{"value":"1096-911X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,1]]}}}