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No lymphoma examined was identified as T\u2010cell in origin. A complete response was obtained in 21 (78%) of 27 patients with measurable disorder. [Gastrectomy rendered one patient disease\u2010free survival, and one partially responded showing a complete reponse after radiotherapy.] Sixteen (76%) of the 21 employed for complete response. After 36 months, elapsed disease\u2010free survival was rated at 100% together with actuarial survival of all patients at 81%. Chemotherapy contributed to reduce the radiation dosage to 3000 rads and to control the areas infiltrated with preexisting tumors. These findings, although the median follow\u2010up time in our study remains short (28 months), provide a strong rationale for further clinical trials of primary chemotherapy, followed by regional radiotherapy for localized stages of non\u2010Hodgkin's lymphomas.<\/jats:p>","DOI":"10.1002\/mpo.2950110409","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T15:40:00Z","timestamp":1171986000000},"page":"251-255","source":"Crossref","is-referenced-by-count":5,"title":["Primary chemotherapy followed by radiotherapy for localized non\u2010hodgkin's lymphomas: A preliminary report"],"prefix":"10.1002","volume":"11","author":[{"given":"Kazumi","family":"Sampi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syozi","family":"Takeoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masao","family":"Hattori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197309)32:3<682::AID-CNCR2820320322>3.0.CO;2-M"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197707)40:1<98::AID-CNCR2820400118>3.0.CO;2-V"},{"key":"e_1_2_1_4_2","unstructured":"ChenMG ProsnitzLR Gonzalez\u2010ServaA FischerDB: Results of radiotherapy in control of stage I and II non\u2010Hodgkin's lym\u2010"},{"key":"e_1_2_1_5_2","first-page":"145","volume-title":"Adjuvant Therapy Cancer II","author":"Bonadonna G","year":"1979"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)91142-3"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197610)38:4<1484::AID-CNCR2820380407>3.0.CO;2-I"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1182\/blood.V49.3.325.325","article-title":"Combination chemotherapy (\u201cCHOP\u2010Bleo.\u201d) in advanced (non\u2010Hodgkin) malignant lymphoma","volume":"49","author":"Rodriquez V","year":"1977","journal-title":"Blood"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197902)43:2<417::AID-CNCR2820430203>3.0.CO;2-I"},{"key":"e_1_2_1_10_2","first-page":"755","article-title":"Some problems on the histopathological diagnosis of non\u2010Hodgkin's malignant tymphoma, a proposal of a new type","volume":"29","author":"Suchi T","year":"1979","journal-title":"Acta Pathol Jpn"},{"key":"e_1_2_1_11_2","first-page":"1860","article-title":"Report of the committee on Hodgkin's disease staging classification","volume":"31","author":"Carbone PP","year":"1971","journal-title":"Cancer Res"},{"key":"e_1_2_1_12_2","first-page":"816","article-title":"Combination chemotherapy of malignant lymphoma","volume":"24","author":"Kimura K","year":"1969","journal-title":"Saishinigaku"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-76-2-227"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-73-6-881"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21979"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)92894-0"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19801201)46:11<2356::AID-CNCR2820461107>3.0.CO;2-X"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00254024"},{"key":"e_1_2_1_19_2","first-page":"322","article-title":"Immunologic approach to non\u2010Hodgkin lymphomas and related leukemias. 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