{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T21:55:09Z","timestamp":1772574909608,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":8236,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[1984,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Serum lactate dehydrogenase activity (LDH) was examined in 66 children with acute lymphoblastic leukemia (ALL), 26 with acute non\u2010lymphocytic leukemia (ANLL), and 116 with non\u2010Hodgkin's lymphoma (NHL). The mean serum LDH value for the ALL and ANLL groups was not significantly different: 970 \u00b1 105 units\/L (mean \u00b1 standard error of the mean) and 817 \u00b1 161 units\/L, respectively. The difference between the LDH values in patients with ALL (970 \u00b1 105 units\/L) and NHL (551 \u00b1 51 units\/L) was significant (<jats:italic>P<\/jats:italic> = .001). In 32% of the patients with ALL and 23% of the patients with ANLL, serum LDH values were above 1000 units\/L, whereas only 13% of the cases with NHL had values above 1000 units\/L. In patients with ALL the LDH levels were correlated with white blood cell counts at the time of diagnosis. In NHL, there was no difference in serum LDH levels among the various histologic subtypes. Values of LDH in stage IV NHL and in ALL were similar.<\/jats:p>","DOI":"10.1002\/mpo.2950120205","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T15:37:03Z","timestamp":1171985823000},"page":"89-92","source":"Crossref","is-referenced-by-count":10,"title":["Serum LDH values in childhood acute leukemias and non\u2010Hodgkin's lymphoma"],"prefix":"10.1002","volume":"12","author":[{"given":"Carlos R.","family":"Suarez","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Andreeff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis R.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1968.tb11917.x"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-90-21985"},{"key":"e_1_2_1_4_2","first-page":"169","article-title":"Burkitt's lymphomas: Prediction of early relapse and metabolic complication of therapy","volume":"15","author":"Anderson T","year":"1974","journal-title":"Proc Am Assoc Cancer Res"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(75)90597-5"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19800701)46:1<139::AID-CNCR2820460122>3.0.CO;2-8"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1182\/blood.V56.3.351.351","article-title":"Serum lactic dehydrogenase (LDH) levels in acute leukemia: Marked elevations in lymphoblastic leukemia","volume":"56","author":"Kornberg A","year":"1980","journal-title":"Blood"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V55.2.282.282"},{"key":"e_1_2_1_9_2","first-page":"442","volume-title":"Tumors of the Hematopoietic System","author":"Rappaport H","year":"1966"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197601)37:1<123::AID-CNCR2820370119>3.0.CO;2-7"},{"key":"e_1_2_1_11_2","volume-title":"The Metabolism of Tumors","author":"Worburg O","year":"1930"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1970.tb07019.x"},{"key":"e_1_2_1_13_2","first-page":"660","article-title":"Correlation of serum lactic dehydrogenase activity with the clinical status of patients with cancer, lymphomas and leukemias","volume":"12","author":"Bierman HR","year":"1957","journal-title":"Cancer Res"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(81)80273-9"},{"key":"e_1_2_1_15_2","first-page":"39","article-title":"Serum lactic dehydrogenase, an indicator of tumor activity in neuroblastoma","volume":"97","author":"Quinn JJ","year":"1981","journal-title":"J Pediatr"},{"key":"e_1_2_1_16_2","first-page":"194","article-title":"Flow cytometry DNA and RNA determination in 107 cases of childhood acute lymphoblastic leukemia: Correlation with FAB classification","volume":"22","author":"Suarez CR","year":"1981","journal-title":"Proc Am Assoc Cancer Res"}],"container-title":["Medical and Pediatric Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmpo.2950120205","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mpo.2950120205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T21:52:03Z","timestamp":1697752323000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mpo.2950120205"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,1]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1984,1]]}},"alternative-id":["10.1002\/mpo.2950120205"],"URL":"https:\/\/doi.org\/10.1002\/mpo.2950120205","archive":["Portico"],"relation":{},"ISSN":["0098-1532","1096-911X"],"issn-type":[{"value":"0098-1532","type":"print"},{"value":"1096-911X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,1]]}}}