{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:21:03Z","timestamp":1760188863256},"reference-count":2,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":8236,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[1984,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although the results of the National Wilms' Tumor Study suggest poor outcome for children with metastases to intra\u2010abdominal, intracranial, skeletal, skin, diaphragm, or mediastinal sites, the incidence and course of mediastinal disease has not been described. Fifty\u2010four newly diagnosed Wilms' tumor patients at Children's Hospital of Michigan (1972\u20101980) were studied for patterns of intrathoracic metastases. All had favorable histology; mean age (MA) at diagnosis was 4.5 years. Initial chemotherapy ranged from single agent to three\u2010drug combination (actinomycin, vincristine, adriamycin). Intrathoracic metastases occurred in 14 (26%) from 0\u201028 months (median, 3.5 months) from diagnosis (MA, 5.8 years). Upon the discovery of intrathoracic metastases all received radiation (1,200\u20102,000 rads) to the chest, some with supplementary doses to the mediastinum. Five children with parenchymal and one with parenchymal and hilar metastases appearing 0\u201028 months after the time of diagnosis survive disease\u2010free 44\u2010127 months after metastases appeared (MA, 6.3 years). Eight children developed parenchymal and mediastinal metastases (MA, 5.4 years). Time from diagnosis to parenchymal metastases was 0\u20107 months; time from diagnosis to mediastinal metastases was 0\u201016 months; and in four, both sites appeared simultaneously. Death occurred in all eight patients 7\u201025 months from diagnosis. Only one child had evidence of recurrence outside the chest. Potential risk factors and influence on survival are discussed.<\/jats:p>","DOI":"10.1002\/mpo.2950120213","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T15:37:03Z","timestamp":1171985823000},"page":"123-126","source":"Crossref","is-referenced-by-count":6,"title":["Significance of mediastinal metastatic disease in Wilms' tumor of favorable histology"],"prefix":"10.1002","volume":"12","author":[{"given":"Barbara A.","family":"Cushing","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr.","given":"Frederick B.","family":"Watts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Joseph","family":"Brough","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arvin I.","family":"Philippart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lakshmi","family":"Das","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810501)47:9<2302::AID-CNCR2820470933>3.0.CO;2-K"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197804)41:4<1577::AID-CNCR2820410448>3.0.CO;2-7"}],"container-title":["Medical and Pediatric Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmpo.2950120213","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mpo.2950120213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T21:51:33Z","timestamp":1697752293000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mpo.2950120213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,1]]},"references-count":2,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1984,1]]}},"alternative-id":["10.1002\/mpo.2950120213"],"URL":"https:\/\/doi.org\/10.1002\/mpo.2950120213","archive":["Portico"],"relation":{},"ISSN":["0098-1532","1096-911X"],"issn-type":[{"value":"0098-1532","type":"print"},{"value":"1096-911X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,1]]}}}