{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:38:58Z","timestamp":1771461538105,"version":"3.50.1"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":8236,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[1984,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In this retrospective multicentric study, we report on early deaths (ie, those that occurred during the first month of treatment) in a total of 943 newly diagnosed ALL pediatric patients registered from 1976 to 1981 at 21 centers of the AIL\u2010AIEOP. Objectives of this study were as follows: (1) to verify the incidence and the cause of early death in a wide population of children with ALL and (2) to elucidate factors associated with early death and therefore to identify \u201chigh\u2010risk\u201d groups of patients.<\/jats:p><jats:p>Out of the 943 ALL patients, 39 (4.1%) early deaths were registered. Main causes were infection, 20 patients (51.3%); hemorrhage, 11 patients (28.3%); uric acid nephropathy, 2 patients (5.1%); cardiac failure, 3 patients (7.6%); syndrome of inappropriate antidiuretic hormone secretion, 1 patient. Two patients died during the first week of unknown cause. Thirteen factors measured at diagnosis and possibly influencing the early death rate were analyzed. Using the chi\u2010square test, only three of these factors (age, mediastinum status, surface markers) appear to have any significant influence on the early death rate.<\/jats:p><jats:p>We also tried to determine how therapy influences this process by analyzing variations in the early death rate, other factors being equal. Significant differences in the early death rates were encountered in AIEOP protocols using different induction regimens.<\/jats:p>","DOI":"10.1002\/mpo.2950120309","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T15:36:14Z","timestamp":1171985774000},"page":"189-193","source":"Crossref","is-referenced-by-count":2,"title":["Early deaths in acute lymphoblastic leukemia (ALL): Results of the Italian pediatric cooperative group for therapy of acute leukemia (AIL\u2010AIEOP)"],"prefix":"10.1002","volume":"12","author":[{"given":"Giorgio","family":"Dini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marida","family":"Bartolini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Massimo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Ceci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Paolucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Calculli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Russo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saverio","family":"Magro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Guazzelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno M.","family":"Cesana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moncilio","family":"Jankovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fausta","family":"Massolo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria T.","family":"Di Tullio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margherita Lo","family":"Curto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonietta","family":"Marchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pier Antonio","family":"Macchia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Mandelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Girolamo","family":"Digilio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Rosati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Acquaviva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrico","family":"Madon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Miniero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Tamaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197808)42:2<781::AID-CNCR2820420250>3.0.CO;2-P"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820701)50:1<150::AID-CNCR2820500128>3.0.CO;2-A"},{"key":"e_1_2_1_4_2","first-page":"119","article-title":"(Italian Association Against Leukemia) Study Group: A cooperative study on the therapy of acute lymphoblastic leukemia. Results of the Italian Association Against Leukemia","volume":"64","author":"AIL","year":"1979","journal-title":"Haematologica"},{"key":"e_1_2_1_5_2","volume-title":"The analysis of binary data","author":"Cox DR","year":"1970"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2964(81)90296-6"},{"key":"e_1_2_1_7_2","unstructured":"MassimoLfor the IPCG for Therapy of Acute Leukemia (AIL\u2010AIEOP): Treatment of acute lymphoblastic leukemia (ALL) in children. Multicentric trials in Italy. In: \u201cProceedings 13th International Cancer Congress.\u201d Seattle Washington September 8\u201315 1982 p66(Abstract)."},{"key":"e_1_2_1_8_2","unstructured":"Amadori S for the IPCG for Therapy of Acute Leukemia (AIL\u2010AIEOP): Treatment of High\u2010Risk Acute Lymphocytic Leukemia (HR\u2010ALL) in children: A randomized multicentric study of two intensive multi\u2010drug regimens. In: \u201c3rd International Symposium on Therapy of Acute Leukemias.\u201d Rome December 11\u201314 1982 p292(Abstract)."},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197312)32:6<1542::AID-CNCR2820320634>3.0.CO;2-D"},{"key":"e_1_2_1_10_2","first-page":"5","article-title":"Assessment of the interrelationship of prognostic factors in childhood acute lymphoblastic leukemia. A report from Children Cancer Study Group","volume":"2","author":"Robinson LL","year":"1980","journal-title":"Am J Pediatr Hematol Oncol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197812)42:6<2641::AID-CNCR2820420620>3.0.CO;2-6"}],"container-title":["Medical and Pediatric Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmpo.2950120309","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mpo.2950120309","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T03:16:30Z","timestamp":1697771790000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mpo.2950120309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,1]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1984,1]]}},"alternative-id":["10.1002\/mpo.2950120309"],"URL":"https:\/\/doi.org\/10.1002\/mpo.2950120309","archive":["Portico"],"relation":{},"ISSN":["0098-1532","1096-911X"],"issn-type":[{"value":"0098-1532","type":"print"},{"value":"1096-911X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1984,1]]}}}