{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T00:01:18Z","timestamp":1789516878309,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":8236,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[1984,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The incidence of testicular infiltrates in 68 boys with acute lymphoblastic leukemia in first remission (1974\u201081), was prospectively investigated through careful clinical examination and routine bilateral biopsies at 2\u20103 years of remission. All boys were under 14 years of age and they were treated with protocols D.74 and Pethema 7\/78. Seven patients (10.3%) presented an isolated testicular relapse (ITR) during the chemotherapy period. In 13 of the 43 testicular biopsies (31%) leukemic infiltrates were found, and in another two findings were controversial. Three boys, two with previous negative biopsies, had an ITR 6 to 18 months after therapy was stopped. Finally, three others had simultaneous relapses in testes and bone marrow, one during chemotherapy and two after suppression. In all, 23 patients (33.8%) in first remission had overt or occult ITR. Overall estimated incidence rate of testes leukemia is 40% in all the groups. Incidence of early and occult ITR was higher in boys with initial WBC counts over 20 \u00d7 10<jats:sup>9<\/jats:sup>\/1. Therapy in ITR generally consisted of local radiotherapy (20\u201025 Gy), a new induction treatment followed by 2\u2010year maintenance treatment; in three patients with early ITR, orchidectomy was also performed and six were given a new CNS preventive treatment. Clinical course in the seven patients with early ITR was unfavourable in five, with subsequent hematological relapses and death; one had a long\u2010term disease\u2010free survival (80 + months) and the other was a recent case. Ten of the 13 patients with occult infiltrates continued in remission and four were off treatment with a follow\u2010up of over 66 months. The three patients with late ITR were in 2nd remission at 8\u201018 months after a new cessation of therapy. It may be concluded from this study that prognosis in ITR is related to the phase of presentation: it is unfavourable in cases of early ITR, but in occult infiltrates, detected by routine biopsy, and in late ITR combined therapy is effective in most cases.<\/jats:p>","DOI":"10.1002\/mpo.2950120606","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T15:54:22Z","timestamp":1171986862000},"page":"386-393","source":"Crossref","is-referenced-by-count":29,"title":["Testicular infiltrates in children with acute lymphoblastic leukemia: A prospective study"],"prefix":"10.1002","volume":"12","author":[{"given":"Juan J.","family":"Ortega","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Javier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuria","family":"Tor\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197504)35:4<1203::AID-CNCR2820350426>3.0.CO;2-3"},{"key":"e_1_2_1_3_2","first-page":"1029","article-title":"Rechute a localization gonadique au cours des leucemies aigues","volume":"6","author":"Schaison G","year":"1977","journal-title":"Nouv Press M\u00e9d"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0308-2261(78)80008-3"},{"key":"e_1_2_1_5_2","first-page":"559","article-title":"Incidencia de la infiltraci\u00f3n testicular en la leucemia linfobl\u00f3stica aguda","volume":"24","author":"Pavlovsky S","year":"1979","journal-title":"Sangre (Barc)"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.1.6109.334"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.58.2.128"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19800415)45:8<2009::AID-CNCR2820450805>3.0.CO;2-A"},{"key":"e_1_2_1_9_2","unstructured":"JacquillatCL WeilM AuclercMF SchaisonG ChastangCL HarousseauJL BautersF OliveD GriscelliCL BonnetM LamagnereJP BernardJ: Application de l'etude des facteurs pronostiques au traitement des l\u00e9ucemies aigues lymphoblastiques de l'enfant. Le protocole 08LA74. Actual Hematol 14eme serie:152\u2013169 1980."},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-67984-1_12"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198303033080902"},{"key":"e_1_2_1_12_2","unstructured":"RiehmH HenzeG LangermanHJ KornhuberB SchellongG: BFM therapy for acute lymphoblastic leukemia 1970\u20131981 in 602 children and adolescents. (Abstract) 3rd Internat. Symposium on Therapy of Acute Leukemias. 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Proceedings of the 7th Meeting International Society of Haematology Barcelona1983 Sept. 11\u201314 p506."},{"key":"e_1_2_1_19_2","first-page":"239","article-title":"Biopsias testiculares a los tres a\u00f1os de remisi\u00f3n continuada en ni\u00f1os con leucemia aguda linfobl\u00e1stica","volume":"14","author":"Ortega JJ","year":"1981","journal-title":"An Esp Pediat"},{"key":"e_1_2_1_20_2","unstructured":"EdenOB RankinA: Testicular biopsies in childhood lymphoblastic leukaemia. (Abstract) 12th Meeting of the Intern Soc of Pediatric Oncology Budapest1980 p32."},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810201)47:3<470::AID-CNCR2820470308>3.0.CO;2-T"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)92623-4"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-67984-1_16"},{"key":"e_1_2_1_24_2","unstructured":"GATLA: \u201cOccult Testicular Relapse.\u201d Buenos Aires: G. A. T. L. A. 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