{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T23:58:01Z","timestamp":1700265481497},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":7870,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[1985,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The incidence of acute and chronic liver damage and its relation to hepatitis B virus (HBV) infection was evaluated in 164 consecutive children with acute leukemia seen in ten Italian hemato\u2010pediatric units. Thirteen out of 164 children (7.9%) had acute hepatitis (AH) during treatment, while 8\/90 (8.8%) showed an acute exacerbation of liver damage within 6 months after therapy withdrawal. Seven of the 13 children with AH while on therapy were HBsAg positive. In 12\/13 cases, liver disease progressed to chronicity. Five of eight children who developed AH after completion of treatment were HBsAg positive. Eighty\u2010nine patients (54.2%) developed biochemical evidence of chronic hepatitis during therapy; 48\/89 were followed after cessation of treatment and 33 of them showed persisting evidence of liver cell necrosis. Thirty\u2010three out of 133 children (24.8%) tested for serum HBsAg were found positive: 26 (78.7%) of them developed chronic hepatitis. Sixty\u2010four out of 133 patients were evaluated after cessation of treatment: Chronic hepatitis persisted in 16\/22 HBsAg\u2010positive (72.7%) and in 17\/42 HBsAg\u2010negative (40.4%) children during follow\u2010up. The outcome of these liver diseases after treatment withdrawal did not differ significantly in relation to HBV serology, suggesting that viral rather than toxic agents were responsible for liver damage also in most HBsAg\u2010negative patients. The high incidence of chronic HBV infection in children with leukemia found in this multicentric study could suggest a need for active immunization with HBV vaccine, but the efficacy of such approach in this clinical setting is still to be validated.<\/jats:p>","DOI":"10.1002\/mpo.2950130409","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T15:52:16Z","timestamp":1171986736000},"page":"203-206","source":"Crossref","is-referenced-by-count":23,"title":["Acute and chronic hepatitis in childhood leukemia: A multicentric study from the italian pediatric cooperative group for therapy of acute leukemia (AIL\u2010AIEOP)"],"prefix":"10.1002","volume":"13","author":[{"given":"A.","family":"Locasciulli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Alberti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Rossetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Santamaria","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Santoro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Madon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Miniero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. 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Rome Italy: 3rd International Symposium of Therapy of Acute Leukemia. December 11\u201314 1982 Abstracts."},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1976.tb03563.x"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(75)90897-1"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-96-4-447"},{"key":"e_1_2_1_11_2","first-page":"371","volume-title":"Progress in liver disease","author":"Bianchi L","year":"1979"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)91392-7"},{"key":"e_1_2_1_13_2","first-page":"354","article-title":"Evidence of non A, non B hepatitis in children with acute leukemia and chronic liver disease","volume":"137","author":"Locasciulli A","year":"1983","journal-title":"Am J Dis Child"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.1890150105"},{"key":"e_1_2_1_15_2","first-page":"96","article-title":"HBsAg carriers among blood donors in Italy; A retrospective survey of data from 189 blood banks","volume":"28","author":"Giusti G","year":"1981","journal-title":"Hepatogastroenterology"}],"container-title":["Medical and Pediatric Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmpo.2950130409","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mpo.2950130409","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T17:21:34Z","timestamp":1697822494000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mpo.2950130409"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,1]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1985,1]]}},"alternative-id":["10.1002\/mpo.2950130409"],"URL":"https:\/\/doi.org\/10.1002\/mpo.2950130409","archive":["Portico"],"relation":{},"ISSN":["0098-1532","1096-911X"],"issn-type":[{"value":"0098-1532","type":"print"},{"value":"1096-911X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,1]]}}}