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Although high affinity (Kd 0.4 nM) progesterone receptors were present in the cytosol of this tumor\u201454 fmole\/mg protein\u2014no cytosolic estradiol receptors could be detected; however, these receptors were found to be tightly bound to the nuclear fraction of the tumor. The nuclear protein had lower apparent Kd for the hormones\u20145.4 nM. This tumor produced and released various steroid hormones. The plasma steroid levels before removal of the tumor were 1,200 pg\/ml for estradiol, 350 pg\/ml for testosterone, and 5 ng\/ml for progesterone. All these steroid hormones declined postoperatively to undetectable levels, with total remission of pubertal signs. Plasma\u2010dehydroepiandrosterione, prolactin, and gonadotropin levels were in the normal range before and after surgery. These results suggest that cytosolic progesterone receptor as an estrogenic marker and\/or nuclear estrogen receptors may predict the hormonal dependency of these estrogen\u2010producing tumors.<\/jats:p>","DOI":"10.1002\/mpo.2950130614","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T15:49:47Z","timestamp":1171986587000},"page":"370-374","source":"Crossref","is-referenced-by-count":6,"title":["Steroid receptors in a granulosa cell tumor (GCT) in an infant with precocious puberty"],"prefix":"10.1002","volume":"13","author":[{"given":"E.","family":"Leiberman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Glezerman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Karny","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Levy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"383","volume-title":"Gynecologic Oncology","author":"McGowan L","year":"1978"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196802)21:2<255::AID-CNCR2820210214>3.0.CO;2-5"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(41)90669-5"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(72)90489-9"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/0002-9378(74)90107-0","article-title":"Estrogen excretion in a case of theca\u2010granulosa cell tumor","volume":"119","author":"Targett CS","year":"1974","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_1_7_2","first-page":"185","article-title":"Hormonal function of a granulosa cell tumor","volume":"48","author":"McCormack TP","year":"1976","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(16)34684-1"},{"key":"e_1_2_1_9_2","first-page":"210","article-title":"Origin of estrogen in isosexual precocious pseudopuberty due to a granulosa\u2010theca cell tumor","volume":"51","author":"Madden JD","year":"1978","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-34-3-521"},{"key":"e_1_2_1_11_2","first-page":"211","volume-title":"Progesterone Receptors in Normal and Neoplastic Tissue","author":"Levy J","year":"1977"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.0760033"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1042\/bj1260561"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198209000-00002"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-1767-9_23"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016348009154094"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810315)47:6<1297::AID-CNCR2820470611>3.0.CO;2-D"},{"key":"e_1_2_1_18_2","first-page":"50","article-title":"Estrogen and progestin binding in cytosols of ovarian adenocarcinomas","volume":"53","author":"Holt JA","year":"1979","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_19_2","first-page":"307","article-title":"Estrogen receptor and peroxidase activity in epithelial ovarian carcinomas","volume":"67","author":"Holt JA","year":"1981","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.0900421"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(82)90021-X"},{"key":"e_1_2_1_22_2","first-page":"229","article-title":"Estrogen receptors in ovarian epithelial carcinoma","volume":"59","author":"Schwartz PE","year":"1982","journal-title":"Obstet Gynecol"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1982.tb05104.x"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1210\/endo-116-2-715"},{"key":"e_1_2_1_25_2","first-page":"615","article-title":"Demonstration of an FSH receptor in a functioning granulosa cell tumor. 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