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Nine patients had received cyclophosphamide and 20 had received radiation therapy. Included in this latter group were five patients who had received radiation therapy to the thorax. Eight patients had acquired pneumonia during their treatment.<\/jats:p><jats:p>Physical examination was normal in all the patients, and none had a history of acute or chronic pulmonary disease. PFT demonstrated an incidence of abnormalities in forced vital capacity (FVC) and\/or total lung capacity (TLC) in 48% of the patients. Patients who were under 3 years of age at the time of diagnosis or who had received radiation to the thorax were more likely to demonstrate PFT abnormalities, but these differences did not reach statistical significance.<\/jats:p><jats:p>The natural history of pulmonary function and subsequent respiratory disease in survivors of childhood cancer requires further definition.<\/jats:p>","DOI":"10.1002\/mpo.2950140403","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T16:13:01Z","timestamp":1171987981000},"page":"202-207","source":"Crossref","is-referenced-by-count":40,"title":["Pulmonary function abnormalities in long\u2010term survivors of childhood cancer"],"prefix":"10.1002","volume":"14","author":[{"given":"Robert W.","family":"Miller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"June E.","family":"Fusner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Fink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas M.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela R.","family":"Getson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jara A.","family":"Vojtova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory H.","family":"Reaman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.129.1.127"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-86-1-81"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1012144"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(77)90424-7"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(80)90364-2"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.246.13.1449"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1542\/peds.55.4.507","article-title":"Effects of therapeutic irradiation delivered in early childhood upon subsequent lung function","volume":"55","author":"Wohl M","year":"1975","journal-title":"Pediatrics"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197606)37:6<2773::AID-CNCR2820370631>3.0.CO;2-6"},{"key":"e_1_2_1_10_2","first-page":"7","article-title":"Epidemiology standardization project","volume":"118","author":"Ferris B","year":"1978","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(80)80039-4"},{"key":"e_1_2_1_12_2","first-page":"1085","article-title":"Five to seven year course of pulmonary function in cystic fibrosis","volume":"114","author":"Corey M","year":"1976","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_1_13_2","unstructured":"CoreyM LevisonH:Standards of pulmonary function. 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