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These changes occur in long term survivors of pediatric malignancy (especially those with prlonged, multimodal, and multicourse therapy), but they may be minimally symptomatic. The changes appear to be analogous to the CNS changes (leukoencephalopathy) described in patients with leukemia and attributed to multimodal therapy.<\/jats:p><jats:p>By taking advantage of opportunities to detect adverse effects earlier in the treatment course, the present excellent cure rate may be improved by refinements in therapy that also improve the quality of survival.<\/jats:p>","DOI":"10.1002\/mpo.2950140505","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T16:12:37Z","timestamp":1171987957000},"page":"262-270","source":"Crossref","is-referenced-by-count":5,"title":["Neuro\u2010ocular damage in pediatric oncology patients: Predictor of long\u2010term visual disability or tool for limiting toxicity?"],"prefix":"10.1002","volume":"14","author":[{"given":"Nancy M.","family":"Newman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Donaldson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"De Wit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oscar","family":"King","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan R.","family":"Wilbur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197502)35:2<291::AID-CNCR2820350202>3.0.CO;2-V"},{"key":"e_1_2_1_3_2","first-page":"1261","article-title":"Leukoencephalopathy following high\u2010dose IV methotrexate chemotherapy with leucovorin rescue","volume":"64","author":"Allen JC","year":"1980","journal-title":"Cancer Treat. 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