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Transient myeloproliferative disorder is well recognized in neonates with a complete or mosaic trisomy 21 (Down's syndrome). We report a phenotypically and cytogenetically normal infant with this syndrome in whom only blast cells showed trisomy 21. We postulate that the pathogenesis of the transient myeloproliferative disorder in both Down's syndrome infants and those with a normal chromosomal complement is related to abnormal prenatal production of placental regulatory hemopoietic factors caused by chromosomal defect(s) confined to placental tissues.<\/jats:p>","DOI":"10.1002\/mpo.2950150109","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T16:10:23Z","timestamp":1171987823000},"page":"38-41","source":"Crossref","is-referenced-by-count":19,"title":["Transient myeloproliferative disorder in chromosomally normal newborn infant"],"prefix":"10.1002","volume":"15","author":[{"given":"D. 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Table of 90%, 15% and 99% confidence limits and comments in use","volume":"29","author":"Hook E","year":"1977","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1980.tb00159.x"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(81)91218-6"},{"key":"e_1_2_1_20_2","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1182\/blood.V59.1.86.86","article-title":"Human trophoblasts; cellular source of colony\u2010stimulating activity in placental tissue","volume":"59","author":"Ruscetti FW","year":"1982","journal-title":"Blood"},{"key":"e_1_2_1_21_2","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1182\/blood.V49.4.573.573","article-title":"Stimulation by human placental conditioned medium of hemopoietic colony formation by human bone marrow cells","volume":"49","author":"Burgess AW","year":"1977","journal-title":"Blood"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6867735"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-70707-0_20"}],"container-title":["Medical and Pediatric Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmpo.2950150109","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mpo.2950150109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T06:43:19Z","timestamp":1697870599000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mpo.2950150109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,1]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1987,1]]}},"alternative-id":["10.1002\/mpo.2950150109"],"URL":"https:\/\/doi.org\/10.1002\/mpo.2950150109","archive":["Portico"],"relation":{},"ISSN":["0098-1532","1096-911X"],"issn-type":[{"value":"0098-1532","type":"print"},{"value":"1096-911X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,1]]}}}