{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T02:21:54Z","timestamp":1780366914866,"version":"3.54.1"},"reference-count":7,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":7140,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[1987,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Our experience in scintigraphic diagnosis using <jats:sup>123<\/jats:sup>l\/<jats:sup>131<\/jats:sup>l\u2010metaiodobenzylguanidme (MIBG) on 37 children with neuroblastomas stage III\u2010IV is reported and discussed, together with the results obtained by other authors on MIBG diagnosis at the International Workshop of Pediatric Oncology held in Rome in September 1986.<\/jats:p><jats:p>In our own investigation, 49 examinations were undertaken with <jats:sup>123<\/jats:sup>l\u2010MIBG and 66 with <jats:sup>131<\/jats:sup>l\u2010MIBG partly under therapy conditions with high\u2010activity doses of <jats:sup>131<\/jats:sup>I\u2010MIBG. There were 29 neuroblastomas, 3 ganglioneuromas, and 3 ganglioneuroblastomas.<\/jats:p><jats:p>The localization of all primary tumors was over 90%; for neuroblastomas with a high level of catecholamine excretion, over 95%. The specificity was about 100%.<\/jats:p><jats:p>The sensitivity with respect to tumor relapse and all localization of metastasis and bone\u2010marrow tumor infiltration in the followup\u2010phase approaches was 70% during or after therapy. What emerges from the experience of most investigators is that <jats:sup>123<\/jats:sup>l\u2010MIBG is the agent best suited to detect tumor relapse and metastasis, especially in the bone marrow. MIBG examinations are of great value in follow\u2010up studies for detecting tumor relapse and bone marrow infiltrations, especially before the onset of clinical symptoms and other indications.<\/jats:p>","DOI":"10.1002\/mpo.2950150408","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T16:09:45Z","timestamp":1171987785000},"page":"181-187","source":"Crossref","is-referenced-by-count":44,"title":["Metaiodobenzylguanidine (MIBG) labeled with <sup>123<\/sup>I\/<sup>131<\/sup>I in neuroblastoma diagnosis and follow\u2010up treatment with a review of the diagnostic results of the international workshop of pediatric oncology held in Rome, september 1986"],"prefix":"10.1002","volume":"15","author":[{"given":"U.","family":"Feine","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"M\u00fcller\u2010Schauenburg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Treuner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T H.","family":"Klingebiel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"474","volume-title":"22nd International Annual Meeting of the Society of Nuclear Medicine\u2014Europe\u2010Helsinki 1984","author":"Feine U","year":"1984"},{"key":"e_1_2_1_3_1","first-page":"484","article-title":"Zum Katecholaminstoffwechsel im Gewebe maligner und benigner Tumoren des sympathischen Nervensystems","volume":"101","author":"K\u00e4ser H","year":"1971","journal-title":"Schweiz Med Wochenschr"},{"key":"e_1_2_1_4_1","first-page":"26","article-title":"Szintigraphische Darstellung eines Neuroblastoms","volume":"14","author":"Kimmig B","year":"1984","journal-title":"Nucl Compact"},{"key":"e_1_2_1_5_1","first-page":"672","article-title":"The normal and abnormal distribution of the adreno\u2010medullary imaging agent m\u2010(I\u2010131) Iodobenzylguanidine (I\u2010131 MIBG) in man: Evaluation by scintigraphy","volume":"24","author":"Nakajo M","year":"1983","journal-title":"J Nucl Med"},{"key":"e_1_2_1_6_1","first-page":"1265","volume-title":"Nuclear Medicine and Biology","author":"Shapiro B","year":"1983"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198107023050103"},{"issue":"4","key":"e_1_2_1_8_1","first-page":"334","article-title":"Scintigraphic imaging of neuroblastoma with (131I)Iodobenzyl\u2010guanidine","author":"Treuner J","year":"1984","journal-title":"Lancet"}],"container-title":["Medical and Pediatric Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmpo.2950150408","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mpo.2950150408","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T06:57:13Z","timestamp":1697871433000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mpo.2950150408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,1]]},"references-count":7,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1987,1]]}},"alternative-id":["10.1002\/mpo.2950150408"],"URL":"https:\/\/doi.org\/10.1002\/mpo.2950150408","archive":["Portico"],"relation":{},"ISSN":["0098-1532","1096-911X"],"issn-type":[{"value":"0098-1532","type":"print"},{"value":"1096-911X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1987,1]]}}}