{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T19:27:01Z","timestamp":1790105221242,"version":"4.0.1"},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":6775,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[1988,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Congenital anomalies were identified in 37 of 115 (32%) children and adolescents autop\u2010sied with rhabdomyosarcoma. An analysis of sex, age, site, and histology of cases with or without congenital anomalies showed no significant differences. Of the 45 identified anomalies, 14 were considered major and 31 minor. The distribution of the anomalies by system included central nervous (9), genitourinary (10), gastrointestinal (13), and cardiovascular systems (4). Ten patients had complex or miscellaneous anomalies. There was one child with each of the following: Rubinstein\u2010Taybi syndrome, neurofibromatosis, single horseshoe kidney, hemihypertrophy, and Arnold\u2010Chiari malformation. Aniridia was not noted in any case of rhabdomyosarcoma. Individuals with rhabdomyosarcoma have an increased incidence of genitourinary anomalies similar to that in Wilms' tumor. Recent molecular genetic investigations have suggeted that rhabdomyosarcoma, Wilms' tumor, and he\u2010patoblastoma share a common pathogenetic mechanism involving chromosome 11. The uniquely increased association of central nervous system anomalies with rhabdomyosarcoma and absence of aniridia would support a different gene locus operative on chromosome 11 for individuals with rhabdomyosarcoma compared to Wilms' tumor. Extensive epidemiologic studies now in progress in patients with rhabdomyosarcoma should provide the incidence of congenital anomalies and potential linkage with prenatal events.<\/jats:p>","DOI":"10.1002\/mpo.2950160109","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T17:56:24Z","timestamp":1171994184000},"page":"33-39","source":"Crossref","is-referenced-by-count":74,"title":["Congenital anomalies associated with rhabdomyosarcoma: An autopsy study of 115 cases. A report from the intergroup rhabdomyosarcoma study committee (representing the children's cancer study group, the pediatric oncology group, the United Kingdom children's cancer study group, and the pediatric intergroup statistical center)"],"prefix":"10.1002","volume":"16","author":[{"given":"Frederick B.","family":"Ruymann","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen R.","family":"Maddux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdel","family":"Ragab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward H.","family":"Soule","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohan","family":"Beltangady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmund A.","family":"Gehan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"William A.","family":"Newton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196404302701802"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196901)23:1<175::AID-CNCR2820230123>3.0.CO;2-2"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-196909000-00001"},{"key":"e_1_2_1_5_2","first-page":"8","volume-title":"Congenital anomalies in children with rhabdomyosarcoma (abstr.)","author":"Ruymann FB","year":"1977"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198404001-01288"},{"key":"e_1_2_1_7_2","first-page":"19","article-title":"Pathology of rhabdomyosarcoma: Experience of the Intergroup Rhabdomyosarcoma Study","volume":"56","author":"Gaiger AM","year":"1981","journal-title":"Nat Cancer Inst Monogr"},{"key":"e_1_2_1_8_2","first-page":"1","volume-title":"Birth Defects: Original Article Series","author":"Myrianthopoulos NC","year":"1974"},{"key":"e_1_2_1_9_2","first-page":"429","article-title":"Epidemiological features of Wilms' tumor: Results of the National Wilms' Tumor Study","volume":"68","author":"Breslow NE","year":"1982","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0022-5347(17)60732-8","article-title":"Horseshoe kidney in children","volume":"108","author":"Segura JW","year":"1972","journal-title":"J Urol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(74)80119-3"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198312153092416"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(72)90006-1"},{"key":"e_1_2_1_14_2","first-page":"527","article-title":"Pancreatic heterotopia: Review of the literature and report of 41 authenticated cases","volume":"82","author":"Barbosa JJ","year":"1946","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-71-4-747"},{"key":"e_1_2_1_16_2","first-page":"1365","article-title":"Rhabdomyosarcoma in children: Epidemiologic study and identification of a familial cancer syndrome","volume":"43","author":"Li FP","year":"1969","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)81233-5"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196308)16:8<1015::AID-CNCR2820160808>3.0.CO;2-I"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80362-X"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197706)39:6<2550::AID-CNCR2820390636>3.0.CO;2-Y"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(76)90048-0"},{"key":"e_1_2_1_22_2","volume-title":"Advances in Neurology, Vol. 29: Neurofibromatosis (Von Recklinghausen's Disease)","author":"Hope DG","year":"1981"},{"key":"e_1_2_1_23_2","first-page":"377","volume-title":"Recognizable Patterns of Human Malformation","author":"Smith DW","year":"1982"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(81)80043-1"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(78)80178-4"},{"key":"e_1_2_1_26_2","first-page":"1083","article-title":"Basal cell nevus syndrome association with congenital rhabdomyosarcoma","volume":"25","author":"Schweisguth O","year":"1968","journal-title":"Arch Fr Pediatr"},{"key":"e_1_2_1_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950110309"},{"key":"e_1_2_1_28_2","first-page":"255","volume-title":"Perspectives in Pediatric Pathology","author":"Sotel\u2010Avila C","year":"1976"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(83)80014-6"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(80)90056-4"},{"key":"e_1_2_1_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/309170a0"},{"key":"e_1_2_1_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/316330a0"},{"key":"e_1_2_1_33_2","first-page":"107","article-title":"Environmental factors in the etiology of rhabdomyosarcoma of childhood","volume":"68","author":"Grufferman S","year":"1982","journal-title":"J Natl Cancer Inst"}],"container-title":["Medical and Pediatric Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmpo.2950160109","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mpo.2950160109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,21]],"date-time":"2023-10-21T14:47:06Z","timestamp":1697899626000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mpo.2950160109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,1]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1988,1]]}},"alternative-id":["10.1002\/mpo.2950160109"],"URL":"https:\/\/doi.org\/10.1002\/mpo.2950160109","archive":["Portico"],"relation":{},"ISSN":["0098-1532","1096-911X"],"issn-type":[{"value":"0098-1532","type":"print"},{"value":"1096-911X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1988,1]]}}}