{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:42:15Z","timestamp":1756993335511},"reference-count":12,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":6409,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[1989,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A patient with chronic lymphocytic leukemia presented with recurrent episodes of severe neutropenia. This neutropenia was initially responsive to prednisone but even tually became refractory. A spindle\u2010cell thymoma was diagnosed and resected with dramatic improvement in his granulocytopenia. Both autologous and heterologous granulocyte macrophage colony growth were clearly inhibited by the patient's serum. This is the first reported case of severe granulocytopenia associated with a thymoma that seemed to be reversed following thymectomy.<\/jats:p>","DOI":"10.1002\/mpo.2950170112","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T17:44:44Z","timestamp":1171993484000},"page":"58-61","source":"Crossref","is-referenced-by-count":13,"title":["Response of agranulocytosis to thymectomy in a patient with thymoma and chronic lymphocytic leukemia"],"prefix":"10.1002","volume":"17","author":[{"suffix":"III","given":"Alva B.","family":"Weir","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lois W.","family":"Dow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"609","volume-title":"Cancer: Principles and Practice of Oncology","author":"Rosenberg JC","year":"1985"},{"issue":"4","key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1182\/blood.V60.4.968.968","article-title":"Syndrome of neutrophil agranulocytosis, hypogammaglobulinemia and thymoma","volume":"60","author":"Degos L","year":"1982","journal-title":"Blood"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.1976.tb03851.x"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1040760111"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1001\/archinte.1984.00350160117020","article-title":"Disorders of the thymus","volume":"144","author":"Rosenow EC","year":"1984","journal-title":"Arch Intern Med"},{"issue":"4","key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1182\/blood.V69.4.1204.1204","article-title":"The syndrome of T8 hyperlymphocytosis: Variation in phenotype and cytotoxic activities of granular cells and evaluation of their role in associated neutropenia","volume":"69","author":"Grillot\u2010Courvalin C","year":"1986","journal-title":"Blood"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830240312"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830230211"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.me.38.020187.000425"},{"issue":"4","key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1182\/blood.V69.4.1161.1161","article-title":"The regulatory role of interleukin\u20102 responsive T lymphocytes on human marrow granulopoiesis","volume":"69","author":"Estiov Z","year":"1987","journal-title":"Blood"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(76)92780-X"},{"issue":"3","key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1182\/blood.V66.3.533.533","article-title":"Hypoplastic anemia in B cell chronic lymphocytic leukemia: Evolution of T cell\u2010mediated suppression of erythropoiseis in early state and late stage disease","volume":"66","author":"Mangan KF","year":"1985","journal-title":"Blood"}],"container-title":["Medical and Pediatric Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmpo.2950170112","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mpo.2950170112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,22]],"date-time":"2023-10-22T16:27:50Z","timestamp":1697992070000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mpo.2950170112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,1]]},"references-count":12,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1989,1]]}},"alternative-id":["10.1002\/mpo.2950170112"],"URL":"https:\/\/doi.org\/10.1002\/mpo.2950170112","archive":["Portico"],"relation":{},"ISSN":["0098-1532","1096-911X"],"issn-type":[{"value":"0098-1532","type":"print"},{"value":"1096-911X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,1]]}}}