{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T23:40:25Z","timestamp":1736811625506,"version":"3.33.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":6409,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[1989,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The prognostic significance of Auer rods in predicting response rate and remission duration was investigated in 257 patients of the two West German acute myelogenous leukemia (AML) studies BFM\u201078 and \u201083. Auer rods were found in 129 children (50%) in the initial bone marrow smear. The incidence was higher in myeloid subtypes M1 (63%) and M2 (78%) compared with subtypes M4 (47%) and M5 (5%) with monocytic differentiation. In both studies, the remission rate was significantly higher in patients with Auer rods (<jats:italic>P<\/jats:italic>= 0.01), and in the study AML\u2010BFM\u201083 a significantly longer remission duration was evaluated for Auer rodpositive patients (<jats:italic>P<\/jats:italic>= 0.007). In the M1 type, Auer rods were of high prognostic significance regarding both the induction success (<jats:italic>P<\/jats:italic>= 0.003) and the remission duration (<jats:italic>P<\/jats:italic>= 0.004), whereas no significant differences between Auer rodpositive and \u2010negative patients in other subtypes were found. Occurrence of Auer rods was independent of hyperleukocytosis, the most powerful prognostic parameter in the studies AML\u2010BFM\u201078 and \u201083, whereas absence of Auer rods was associated with the AML risk group M5. In the M1 type, Auer rod\u2010negative leukemias appeared to represent cases of poorly differentiated AML. Auer rods were therefore useful in differentiating between patients with a poor and a more favorable prognosis, particularly in the M1 type.<\/jats:p>","DOI":"10.1002\/mpo.2950170307","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T17:44:26Z","timestamp":1171993466000},"page":"202-209","source":"Crossref","is-referenced-by-count":11,"title":["Prognostic significance of auer rods in childhood acute myelogenous leukemia: Results of the studies AML\u2010BFM\u201078 and \u221283"],"prefix":"10.1002","volume":"17","author":[{"given":"J\u00f6rg","family":"Ritter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josef","family":"Vormoor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ursula","family":"Creutzig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcnther","family":"Schellong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"volume-title":"Recent Results in Cancer Research","author":"Creutzig U","key":"e_1_2_1_2_2"},{"key":"e_1_2_1_3_2","first-page":"88","volume-title":"Haematology and Blood Transfusion, Vol. 30, Acute Leukemias","author":"Weinstein H","year":"1987"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/978-3-642-96889-1_12","volume-title":"Cancer in Children\u2014Clinical Management","author":"Riehm H","year":"1986"},{"doi-asserted-by":"publisher","key":"e_1_2_1_5_2","DOI":"10.1200\/JCO.1985.3.1.3"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1182\/blood.V61.5.867.867","article-title":"Relationship of megakaryocyte size at diagnosis to chemotherapeutic response in children with acute nonlymphocytic leukemia","volume":"61","author":"Jackson CW","year":"1983","journal-title":"Blood"},{"doi-asserted-by":"publisher","key":"e_1_2_1_7_2","DOI":"10.1097\/00043426-198724000-00009"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1365-2141.1982.tb08475.x","article-title":"The French\u2010American\u2010British (FAB) Co\u2010operative Group: Proposals for the classification of the myelodysplastic syndromes","volume":"51","author":"Bennett JM","year":"1982","journal-title":"Br J Haematol"},{"doi-asserted-by":"publisher","key":"e_1_2_1_9_2","DOI":"10.1093\/ajcp\/68.5.616"},{"key":"e_1_2_1_10_2","first-page":"459","article-title":"Prime osservazioni al microscopio elettronico di due casi di leucemia basophila acuta","volume":"46","author":"Cecio A","year":"1970","journal-title":"Boll Soc It Biol Sper"},{"key":"e_1_2_1_11_2","first-page":"71","volume-title":"Advances in the Biosciences 14, Workshop on Prognostic Factors in Human Acute Leukemia","author":"Henderson ES","year":"1975"},{"key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1182\/blood.V56.5.773.773","article-title":"Morphological classification, response to therapy, and survival in 263 adult patients with acute nonlymphoblastic leukemia","volume":"56","author":"Mertelsmann R","year":"1980","journal-title":"Blood"},{"doi-asserted-by":"publisher","key":"e_1_2_1_13_2","DOI":"10.1007\/978-94-009-7433-3_8"},{"doi-asserted-by":"publisher","key":"e_1_2_1_14_2","DOI":"10.1002\/1097-0142(19840401)53:7<1526::AID-CNCR2820530718>3.0.CO;2-2"},{"doi-asserted-by":"publisher","key":"e_1_2_1_15_2","DOI":"10.1016\/0145-2126(85)90150-X"},{"doi-asserted-by":"publisher","key":"e_1_2_1_16_2","DOI":"10.1111\/j.1365-2141.1986.tb02200.x"},{"key":"e_1_2_1_17_2","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1182\/blood.V65.2.298.298","article-title":"Improved treatment results in childhood acute myelogenous leukemia: A report of the German cooperative study AML\u2010BFM\u201078","volume":"65","author":"Creutzig U","year":"1985","journal-title":"Blood"},{"doi-asserted-by":"publisher","key":"e_1_2_1_18_2","DOI":"10.1111\/j.1365-2141.1976.tb03563.x"},{"doi-asserted-by":"publisher","key":"e_1_2_1_19_2","DOI":"10.7326\/0003-4819-103-3-460"},{"doi-asserted-by":"publisher","key":"e_1_2_1_20_2","DOI":"10.7326\/0003-4819-103-4-620"},{"doi-asserted-by":"publisher","key":"e_1_2_1_21_2","DOI":"10.1080\/01621459.1958.10501452"},{"doi-asserted-by":"publisher","key":"e_1_2_1_22_2","DOI":"10.2307\/2529177"},{"doi-asserted-by":"publisher","key":"e_1_2_1_23_2","DOI":"10.1007\/978-3-662-05748-3"},{"key":"e_1_2_1_24_2","first-page":"419","article-title":"Three types of Auer bodies in acute leukemia, visualization of their protein by negative contrast after peroxidase cytochemistry","volume":"41","author":"Tulliez M","year":"1979","journal-title":"Lab Invest"},{"doi-asserted-by":"publisher","key":"e_1_2_1_25_2","DOI":"10.1002\/1097-0142(19871215)60:12<3071::AID-CNCR2820601235>3.0.CO;2-Y"},{"key":"e_1_2_1_26_2","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1182\/blood.V49.5.693.693","article-title":"Abnormalities in granule formation in acute myelogenous leukemia","volume":"49","author":"Bainton DF","year":"1977","journal-title":"Blood"},{"key":"e_1_2_1_27_2","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1093\/ajcp\/81.1.132","article-title":"The ultrastructural identification of Auer body precursors in a case of acute promyelocytic leukemia using high\u2010angle specimen tilt","volume":"81","author":"Dixon BR","year":"1984","journal-title":"Am J Pathol"},{"doi-asserted-by":"publisher","key":"e_1_2_1_28_2","DOI":"10.1007\/BF01721212"},{"key":"e_1_2_1_29_2","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1182\/blood.V64.4.875.875","article-title":"Acute monoblastic leukemia in infancy and early childhood: Successful treatment with an epipodophylotoxin","volume":"64","author":"Odom LF","year":"1984","journal-title":"Blood"},{"doi-asserted-by":"publisher","key":"e_1_2_1_30_2","DOI":"10.1002\/1097-0142(19851001)56:7<1584::AID-CNCR2820560720>3.0.CO;2-L"},{"key":"e_1_2_1_31_2","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1182\/blood.V70.5.1400.1400","article-title":"Minimally differentiated acute nonlymphocytic leukemia: A distinct entity","volume":"70","author":"Lee EJ","year":"1987","journal-title":"Blood"}],"container-title":["Medical and Pediatric Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmpo.2950170307","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mpo.2950170307","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T23:13:41Z","timestamp":1736810021000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mpo.2950170307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,1]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1989,1]]}},"alternative-id":["10.1002\/mpo.2950170307"],"URL":"https:\/\/doi.org\/10.1002\/mpo.2950170307","archive":["Portico"],"relation":{},"ISSN":["0098-1532","1096-911X"],"issn-type":[{"type":"print","value":"0098-1532"},{"type":"electronic","value":"1096-911X"}],"subject":[],"published":{"date-parts":[[1989,1]]}}}