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The case of a 2\u2010year\u2010old boy with acute lymphocytic leukemia and HMSN\u2010I is reported, and additional cases from the literature are reviewed. Severe vincristine neurotoxicity in patients with HMSN\u2010I may be secondary to impairment of both slow andfast axonal transport. Vincristine should be used with caution in patients with a family history of polyneuropathy.<\/jats:p>","DOI":"10.1002\/mpo.2950170534","type":"journal-article","created":{"date-parts":[[2008,9,24]],"date-time":"2008-09-24T14:30:28Z","timestamp":1222266628000},"page":"520-523","source":"Crossref","is-referenced-by-count":38,"title":["Acute vincristine neurotoxicity in the presence of hereditary motor and sensory neuropathy type I"],"prefix":"10.1002","volume":"17","author":[{"given":"Stephen A.","family":"McGuire","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"Sidney M.","family":"Gospe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Dahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03259853"},{"key":"e_1_2_1_3_2","first-page":"388","article-title":"Evidence for linkage of Charcot\u2010Marie\u2010Tooth neuropathy to the Duffy locus on chromosome I","volume":"34","author":"Bird TD","year":"1982","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_4_2","first-page":"430","article-title":"Linkage evidence for genetic heterogeneity among kinships with hereditary motor and sensory neuropathy type I","volume":"58","author":"Dyck PJ","year":"1983","journal-title":"Mayo Clin Proc"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950140313"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197206222862523"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1984.03350200048021"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.254.4.507b"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.5694\/j.1326-5377.1985.tb123018.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1987.tb00168.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(81)80785-8"},{"key":"e_1_2_1_12_2","first-page":"2098","volume-title":"Myology","author":"Dyck PJ","year":"1986"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410140608"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410160213"},{"key":"e_1_2_1_15_2","first-page":"1051","volume-title":"Cold Spring Harbor Conference on Cell Proliferation. 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