{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T13:11:35Z","timestamp":1698066695151},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":6044,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[1990,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The acute leukemias have been considered to represent a clonal expansion of a malignant transformed hematopoietic progenitor cell with adherence to either the myeloid or lymphoid lineage\u2014\u201clineage fidelity.\u201d Lineage fidelity has been challenged by the demonstration of lineage switching or mixed\u2010lineage leukemias. We describe a 7 year old male who presented with undifferentiated acute leukemia and nasopharyngeal and cervical masses. His blasts had the morphologic appearance of myeloblasts (FAB M1) and were positive solely for the myeloid antigen CD15. He entered a complete remission (CR) with acute nonlymphocytic leukemia therapy. At first relapse he had evidence of mixed\u2010lineage leukemia with B\u2010cell lymphoid and myeloid phenotypes. He again relapsed from a second CR with Burkitt\u2010cell leukemia. Cytogenetic findings showed a consistent 14q+,17p+ abnormality in the blasts and nasopharyngeal mass. The t(8;14) associated with Burkitt's lymphoma was found in the mass tissue only following passage in the nude mouse.<\/jats:p><jats:p>Our patient demonstrates that limitations still exist in our ability to classify acute leukemia. That leukemic transformation occurred in a multipotential progenitor cell leading to undifferentiated leukemia at diagnosis and\/or that chemotherapy can influence the genetic programs of leukemic cells leading to the evidence of mixed\u2010lineage leukemia and lineage switching is supported.<\/jats:p>","DOI":"10.1002\/mpo.2950180104","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T18:10:00Z","timestamp":1171995000000},"page":"15-21","source":"Crossref","is-referenced-by-count":0,"title":["Undifferentiated acute leukemia and lineage infidelity (difficulties in classification and management)"],"prefix":"10.1002","volume":"18","author":[{"given":"Cynthia A.","family":"Delaat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatrice","family":"Files","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard E.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Neudorf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatrice C.","family":"Lampkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.959840"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.1041130418"},{"key":"e_1_2_1_4_2","first-page":"205","article-title":"Clonal origin of leukemia","volume":"7","author":"Boggs DR","year":"1981","journal-title":"Blood Cells"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1182\/blood.V66.4.902.902","article-title":"Evidence for clonal development of childhood acute lymphoblastic leukemia","volume":"66","author":"Dow LW","year":"1985","journal-title":"Blood"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V61.6.1138.1138"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1182\/blood.V65.1.142.142","article-title":"Simultaneous or sequential expression of lymphoid and myeloid phenotypes in acute leukemia","volume":"65","author":"Neame PB","year":"1985","journal-title":"Blood"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V66.5.1115.1115"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1984.tb01277.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(84)90046-8"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(84)90032-8"},{"issue":"2","key":"e_1_2_1_12_2","first-page":"117","article-title":"Acute leukemia with lymphoid\/myeloid cell populations (Hybrid leukemia). 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