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We report a series of six consecutive patients, ranging in age from newborn to 5.75 years with hepatoblastoma unresectable at presentation, either because of size of tumor or its anatomical boundaries, or because of metastatic disease. All were treated with preoperative continuous infusions of <jats:italic>cis<\/jats:italic>\u2010platinum and Adriamycin. All achieved resect\u2010ability, and there was only one operative death. The five surviving patients are alive and free of disease off therapy. Potential benefit may accrue from preoperative chemotherapy in most cases of hepatoblastoma.<\/jats:p>","DOI":"10.1002\/mpo.2950180303","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T18:08:20Z","timestamp":1171994900000},"page":"181-184","source":"Crossref","is-referenced-by-count":14,"title":["Adriamycin and cis\u2010platinum administered by continuous infusion preoperatively in hepatoblastoma unresectable at presentation"],"prefix":"10.1002","volume":"18","author":[{"given":"A. M.","family":"Langevin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Pierro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. 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