{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T21:49:59Z","timestamp":1761947399577},"reference-count":32,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":5679,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[1991,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>From 1974 to 1987, 450 children with non\u2010Hodgkins' lymphoma (NHL) were seen at the Institut Gustave Roussy (IGR); 14 children had malignant lymphoma of bone (MLB). Eleven of the 14 were newly diagnosed, whereas three presented in relapse. Nine patients presented with multifocal bone involvement. The median age of these eight girls and six boys was 9.5 years (range 1.25\u201315 years). Bone pain was present in all patients as the initial symptom. Evaluation included physical examination, routine serum chemistries, complete blood count, chest roentgenography, skeletal survey, radionuclide bone scan, lumbar puncture, bone marrow aspiration, and intravenous pyelography, and\/or abdominal ultrasonography. Hypercalcemia was found in six patients. Biopsy was performed in 12 patients, revealing high\u2010grade lymphoblastic lymphomas in all. In two patients diagnosis was made on cytological examination of bone marrow aspirate. Immunophenotyping in four cases, demonstrated non\u2010B, non\u2010T cell origin in three and pre\u2010B cell origin in one. Three patients were treated prior to 1982 with Cyclophosphamide\/Oncovin\/Prednisone\/ADriamycin (COPAD) and seven patients, seen after 1982, were treated with a modified LSA<jats:sub>2<\/jats:sub>L<jats:sub>2<\/jats:sub> protocol (LMT). None of the previously untreated patients received radiotherapy. All patients treated with CO\u2010PAD have died, whereas four out of seven treated with LMT are alive with a median follow up of 51 months (range 36\u201382 months). One child treated on a pilot study died. One of the three children seen at relapse is disease\u2010free with a follow\u2010up of 98 months after high\u2010dose chemotherapy followed by autologous bone marrow transplantation (ABMT). Five out of six patients presenting with hypercalcemia have died. Results with LMT are encouraging and together with published results suggest that sufficiently intensive chemotherapy can result in complete remission and cure in MLB. Radiotherapy does not seem to be necessary, avoiding possible serious long\u2010term effects. Hypercalcemia is a bad prognostic feature.<\/jats:p>","DOI":"10.1002\/mpo.2950190105","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T18:06:08Z","timestamp":1171994768000},"page":"22-27","source":"Crossref","is-referenced-by-count":27,"title":["Childhood malignant lymphoma of bone"],"prefix":"10.1002","volume":"19","author":[{"given":"Max J.","family":"Coppes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine","family":"Patte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Couanet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Michel","family":"Caillaud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emile","family":"Salloum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurence","family":"Brugi\u00e8res","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivier","family":"Hartmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chantal","family":"Kalifa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Bernard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Lemerle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19861215)58:12<2646::AID-CNCR2820581217>3.0.CO;2-U"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-87-1-50"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1182\/blood.V72.4.1141.1141","article-title":"Bone involvement in young patients with non\u2010Hodgkin's lymphoma: efficacy of chemotherapy without local radiotherapy","volume":"72","author":"Haddy TB","year":"1988","journal-title":"Blood"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197912)44:6<1990::AID-CNCR2820440605>3.0.CO;2-9"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870115)59:2<335::AID-CNCR2820590228>3.0.CO;2-#"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1986.4.4.496"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1200\/JCO.1989.7.9.1275","article-title":"Primary lymphoma of bone in children","volume":"7","author":"Furman WL","year":"1989","journal-title":"J Clin Oncol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19871115)60:10<2494::AID-CNCR2820601025>3.0.CO;2-M"},{"key":"e_1_2_1_10_2","first-page":"407","article-title":"Malignant lymphoma of bone (mLB) in childhood","volume":"16","author":"Coppes MJ","year":"1988","journal-title":"Med Pediatr Oncol"},{"key":"e_1_2_1_11_2","first-page":"265","article-title":"Prognostic factors and obstacles to cure of childhood non\u2010Hodgkin's lymphoma","volume":"4","author":"Murphy SB","year":"1977","journal-title":"Semin Oncol"},{"key":"e_1_2_1_12_2","first-page":"406","article-title":"Classification of non\u2010Hodgkin's lymphomas (letter to the Editor)","author":"Gerard\u2010Marchant R","year":"1974","journal-title":"Lancet"},{"key":"e_1_2_1_13_2","volume-title":"WHO International Histological Classification of Tumors, 14","author":"Mathe G","year":"1976"},{"key":"e_1_2_1_14_2","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1182\/blood.V59.4.809.809","article-title":"Changes in surface antigens on malignant T cells from lymphoblastic lymphomas at relapse: An appraisal with monoclonal antibodies and microfluorometry","volume":"59","author":"Bernard A","year":"1982","journal-title":"Blood"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V59.3.549.549"},{"key":"e_1_2_1_16_2","first-page":"321","article-title":"R\u00e9sultats du traitement de 178 lymphomes malins nonhodgkiniens de l'enfant de 1973 \u00e0 1978","volume":"38","author":"Patte C","year":"1981","journal-title":"Arch Fr P\u00e9diatr"},{"key":"e_1_2_1_17_2","first-page":"141","volume-title":"Cancer in children","author":"Lemerle J","year":"1986"},{"key":"e_1_2_1_18_2","unstructured":"PatteC KalifaC BernardA HartmannO FlamantF CaillaudJM BayleC LemerleG:LSA2\u2010L2 protocol modified by the adjunction of high dose methotrexate (hD MTX): Results on 47 children with lymphoblastic non Hodgkin's disease. 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