{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T16:36:49Z","timestamp":1761237409735},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":5679,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[1991,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rhabdomyosarcoma of the larynx is a malignant disease rerely seen in children. We present five cases (3 males, 2 females) observed among 126 patients with rhabdomyosarcoma of the head and neck (excluding the orbit) treated in the Institut Custave\u2010Roussy between 1955 and 1981.<\/jats:p><jats:p>The patients were aged between 51\/2 years and 131\/2 years at the time of diagnosis. The presenting symptoms were dysphonia and\/or dyspnea; tracheotomy was required in two cases. All five patients received chemotherapy consisting of vincristine, cyclophosphamide, actinomycin D + procarbazine or doxorubicine. Four patients also received radiotherapy (45 Gy during 5 weeks). Laryngectomy was not performed. Treatment sequelae included regional hypoplasia, huskiness, and subclinical thyroid insufficiency; two patients developed a benign thyroid adenoma. One patient presented a bilateral carotid stenosis subsequent to radiotherapy performed on \u201cwide fields\u201d portal designed to provided prophylactic treatment on uninvolved lymph nodes. All the patients are alive and relapse\u2010free with a follow\u2010up of between 13 and 17 years.<\/jats:p><jats:p>This small series of RMS of the larynx shows that patients can be cured without laryngectomy, although long\u2010term sequelae associated with radiotherapy are observed.<\/jats:p>","DOI":"10.1002\/mpo.2950190208","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T18:01:06Z","timestamp":1171994466000},"page":"110-114","source":"Crossref","is-referenced-by-count":23,"title":["Rhabdomyosarcoma of the larynx in children: A series of five patients treated in the Institut Gustave Roussy (Villejuif, France)"],"prefix":"10.1002","volume":"19","author":[{"given":"Mara A. D. 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