{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:31:04Z","timestamp":1700008264108},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":5314,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[1992,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Seven consecutive autologous bone marrow transplants were performed in children with neuroblastoma with very good partial remission (VGPR). A combination of cyclophosphamide, escalating doses of VP\u201016\u2010213, continuous infusion vincristine, and total body irradiation followed by infusion with unpurged bone marrow was used. The dose\u2010limiting toxicity in this regimen was mucositis which occurred when the total dose of VP\u201016\u2010213 was 2,400 mg\/m<jats:sup>2<\/jats:sup>. The response rate to this regimen was 4\/7 (\u2010CR 48+, 21+, 21+, 35+ mo) 3\/7 had a CR\/PR post transplant with progressive disease between 1 and 4 months later (mean 2.6 mo). We conclude that this regimen is well tolerated when the maximum dose of VP\u201016\u2010213 does not exceed 1,800 mg\/m<jats:sup>2<\/jats:sup>. Further evaluation will be necessary with this regimen to determine its therapeutic value in a larger number of patients with neuroblastoma.<\/jats:p>","DOI":"10.1002\/mpo.2950200114","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T18:23:01Z","timestamp":1171995781000},"page":"64-67","source":"Crossref","is-referenced-by-count":4,"title":["Single institution experience with high\u2010dose cyclophosphamide, continuous infusion vincristine, escalating doses of VP\u201016\u2010213, and total body irradiation with unpurged bone marrow rescue in children with neuroblastoma"],"prefix":"10.1002","volume":"20","author":[{"given":"Morris","family":"Kletzel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David L.","family":"Becton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. H.","family":"Berry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"303","volume-title":"Clinical Pediatric Oncology","author":"Lansky SB","year":"1984"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.3109\/08880018509141221"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0308-2261(86)80003-0"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198712243172602"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820201)49:3<603::AID-CNCR2820490334>3.0.CO;2-H"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1984.tb06105.x"},{"issue":"6","key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1200\/JCO.1983.1.6.359","article-title":"Intensive melphalan chemotherapy and cryopreserved autologous bone marrow transplantation for the treatment of refractory cancer","volume":"1","author":"Lazurus HM","year":"1983","journal-title":"J Clin Oncol"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198708203170801"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197202)29:2<357::AID-CNCR2820290215>3.0.CO;2-M"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1200\/JCO.1983.1.11.701","article-title":"High dose VP\u201016\u2010213 and autologous bone marrow transplantation for refractory malignancies: A phase I study","volume":"1","author":"Wolff SN","year":"1983","journal-title":"J Clin Oncol"},{"key":"e_1_2_1_12_2","first-page":"86","article-title":"Intensive cytoreductive regimen and autologous bone marrow transplantation in leukemias and solid tumors (a review)","volume":"14","author":"Philip T","year":"1982","journal-title":"Transplant Clin Immunol"},{"key":"e_1_2_1_13_2","first-page":"569","volume-title":"Advances in Neuroblastoma Research","author":"Philip T","year":"1985"},{"key":"e_1_2_1_13_3","first-page":"569","volume":"175","year":"1985","journal-title":"Prog Clin Biol Res"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197909)44:3<896::AID-CNCR2820440316>3.0.CO;2-9"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(72)80381-0"},{"issue":"6","key":"e_1_2_1_16_2","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1001\/archderm.1987.01660300067014","article-title":"Acute graft\u2010vs\u2010host disease. Development following autologous and syngeneic bone marrow transplantation","volume":"123","author":"Hood AF","year":"1987","journal-title":"Arch Dermatol"},{"issue":"2","key":"e_1_2_1_17_2","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1542\/peds.67.2.217","article-title":"Fatal graft vs. host disease following a blood transfusion in a child with neuroblastoma","volume":"67","author":"Woods WG","year":"1981","journal-title":"Pediatrics"},{"issue":"1","key":"e_1_2_1_18_2","first-page":"3","article-title":"The role of marrow autografting in neuroblastoma","volume":"4","author":"Graham JP","year":"1989","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6719137"}],"container-title":["Medical and Pediatric Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmpo.2950200114","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mpo.2950200114","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T13:39:22Z","timestamp":1698068362000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mpo.2950200114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,1]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1992,1]]}},"alternative-id":["10.1002\/mpo.2950200114"],"URL":"https:\/\/doi.org\/10.1002\/mpo.2950200114","archive":["Portico"],"relation":{},"ISSN":["0098-1532","1096-911X"],"issn-type":[{"value":"0098-1532","type":"print"},{"value":"1096-911X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,1]]}}}