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Secondary acute lymphoblastic leukemia has rarely been reported in either adult or childhood cancer. We report the development of acute T\u2010cell lymphoblastic leukemia in a child following successful treatment of a paravertebral embryonal rhabdomyosarcoma (ERS). Southern blot analysis of DNA extracted from the T\u2010cell lymphoblasts, using probes homologous to loci on the short arm of chromosome 11; P\u2010calcitonin, P40.1 and H\u2010<jats:italic>ras<\/jats:italic>, did not demonstrate the chromosomal loss of heterozygosity (LOH), a common feature of embryonal rhabdomyosarcoma. The data presented support the assumption that de novo leukemia emerged following treatment of the primary malignancy. \u00a9 1992 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mpo.2950200310","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T18:20:14Z","timestamp":1171995614000},"page":"229-231","source":"Crossref","is-referenced-by-count":12,"title":["T\u2010cell acute lymphoblastic leukemia following therapy of rhabdomyosarcoma"],"prefix":"10.1002","volume":"20","author":[{"given":"Chaim","family":"Kaplinsky","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amos","family":"Frisch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ian J.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yacov","family":"Goshen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lutfi","family":"Jaber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isaar","family":"Yaniv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Batia","family":"Stark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanah","family":"Tamary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rina","family":"Zaizov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199001043220102"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199001043220101"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197910043011402"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198311033091802"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1984.2.5.385"},{"issue":"3","key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1093\/jnci\/78.3.459","article-title":"Leukemia after therapy with alkylating agents for childhood cancer","volume":"78","author":"Tucker MA","year":"1987","journal-title":"JNCI"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(84)34127-6"},{"issue":"3","key":"e_1_2_1_9_2","first-page":"208","article-title":"ALL secondary to Ewing's sarcoma treated by a combination of surgery\u2010radiotherapy\u2010chemotherapy","volume":"135","author":"Turpin F","year":"1984","journal-title":"Ann Intern Med"},{"issue":"2","key":"e_1_2_1_10_2","first-page":"158","article-title":"Secondary leukemia following successful treatment of Wilm's tumor","volume":"11","author":"Moss TJ","year":"1989","journal-title":"Am J Pediatr Hematol\/Oncol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870010106"},{"key":"e_1_2_1_12_2","first-page":"287","article-title":"Late effects of therapy in rhabdomyosarcoma","volume":"54","author":"Heyn RM","year":"1985","journal-title":"Clin Oncol"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860515)57:10<2070::AID-CNCR2820571032>3.0.CO;2-G"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1988.tb02400.x"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1001\/archinte.1979.03630410067021","article-title":"Acute leukemia and immunosuppressive drug use. 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