{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,8]],"date-time":"2024-09-08T17:38:27Z","timestamp":1725817107493},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":4948,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Carboplatin is an effective chemotherapeutic agent against many solid tumours. Although it is thought to be less nephrotoxic than its precursor cisplatin, current paediatric treatment protocols require regular monitoring of renal glomerular function during and after carboplatin use. Because accurate assessment of renal function in children requires measurement of isotope\u2010clearance glomerular filtration rates (GFRs), routine monitoring is costly and time consuming. We studied 26 paediatric patients who were receiving chemotherapy that included 500\u2013600 mg\/m<jats:sup>2<\/jats:sup> of carboplatin per course. <jats:sup>51<\/jats:sup>Cr\u2010EDTA GFRs were measured initially and after one to seven courses (median four). There was no measurable difference between renal function before and after carboplatin (<jats:italic>P<\/jats:italic> = 0.8). Our study shows that routine monitoring of renal glomerular function is unnecessary. Carboplatin use in patients who have had unilateral nephrectomy as part of their treatment is also discussed. Paediatric oncology literature concerning nephrotoxicity and carboplatin is reviewed. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mpo.2950210107","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T19:06:14Z","timestamp":1171998374000},"page":"31-35","source":"Crossref","is-referenced-by-count":11,"title":["Nephrotoxicity following carboplatin use in children: Is routine monitoring of renal function necessary?"],"prefix":"10.1002","volume":"21","author":[{"given":"Laura J.","family":"Brandt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie","family":"Broadbent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(85)80098-6"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(67)92781-X"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1989.233"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1991.144"},{"key":"e_1_2_1_6_2","first-page":"1039","article-title":"Pediatric phase I trial of carboplatin: A Childrens Cancer Study Group report","volume":"71","author":"Gaynon PS","year":"1987","journal-title":"Cancer Treat Rep"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1987.5.3.459"},{"key":"e_1_2_1_8_2","unstructured":"KalifaC FlamantF HartmannO VassalG LemerleJ:Postsurgical chemotherapy without radiation therapy in patients less than three years with malignant brain tumors. 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