{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T18:11:01Z","timestamp":1759515061533},"reference-count":30,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":4948,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Seventy\u2010two Turkish children with Burkitt's lymphoma (BL) observed during a period of 22 years (1968\u20131990) have been analysed retrospectively. The diagnosis was established histologically according to WHO criteria. BL represented 50% of NHL in this series. The patients were staged according to Ziegler's system. The median age of patients was 5.5 years with a sex (M\/F) ratio of 2.1\/1. The most common primary site of tumor involvement was the abdomen (69.4%), which was followed by facial tumors, in particular the jaw and orbit (49.9%). There were 21 cases with jaw (29.1%) and 15 cases with orbital involvement (20.8%) at initial presentation. The majority of the patients (84.4%) were in advanced stages (C and D) at initial diagnosis. Facial tumors observed in Turkish children with BL were more similar to African Burkitt's lymphoma than American or European cases. High titers of antibodies against VCA and EA of EBV were also seen in our recent cases of BL. Two main treatment regimens, namely, single agent chemotherapy with cyclophosphamide (CYX) (1968\u20131974) and three drug (COM) combination chemotherapy, were used consecutively (1974\u20131988). COM has been shown to produce better results than single agent therapy. The clinical presentation, mean age, and high antibodies (lgG) to EBV and preliminary molecular studies revealed that BL appears to be in between African and non\u2010African types in Turkish children. This will be further elucidated by direct examination of tumor cells for EBV and investigation of the molecular characteristics of Turkish tumors. Such studies are presently under way. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mpo.2950210108","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T19:06:14Z","timestamp":1171998374000},"page":"36-42","source":"Crossref","is-referenced-by-count":26,"title":["Burkitt's lymphoma between African and American types in Turkish children: Clinical, viral (EBV), and molecular studies"],"prefix":"10.1002","volume":"21","author":[{"given":"Ayhan O.","family":"\u00c7avdar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sevgi","family":"G\u00f6zda\u015fo\u01e7lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fclsan","family":"Yavuz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emel","family":"Babacan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emel","family":"\u00dcnal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d6mer","family":"Uluo\u01e7clu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sel\u00e7uk","family":"Y\u00fccesan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I. T.","family":"Magrath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nejat","family":"Akar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.18004619704"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196103\/04)14:2<258::AID-CNCR2820140206>3.0.CO;2-7"},{"key":"e_1_2_1_4_2","first-page":"483","volume-title":"Clinical Pediatric Oncology","author":"White L","year":"1984"},{"key":"e_1_2_1_5_2","first-page":"136","volume-title":"Pediatric Oncology","author":"Shende A","year":"1983"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197707142970202"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197602)37:2<671::AID-CNCR2820370210>3.0.CO;2-D"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197612)38:6<2225::AID-CNCR2820380606>3.0.CO;2-F"},{"key":"e_1_2_1_9_2","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1182\/blood.V36.6.718.718","article-title":"Central nervous system involvement in Burkitt's Lymphoma","volume":"36","author":"Ziegler JL","year":"1970","journal-title":"Blood"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199122000-00019"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1182\/blood.V63.5.1102.1102","article-title":"An effective therapy for both undifferentiated (including Burkitt's) lymphomas and lymphoblastic lymphomas in children and young adults","volume":"63","author":"Magrath IT","year":"1986","journal-title":"Blood"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19800315)45:6<1507::AID-CNCR2820450634>3.0.CO;2-D"},{"key":"e_1_2_1_13_2","unstructured":"\u00c7avdarAO G\u00f6zda\u015fo\u01e7luS P\u00fcrselimA:A case of Burkitt's lymphoma in Turkey. VthCongress of Asian and Pacific Society of Haematology (abs.)1969 p.107."},{"key":"e_1_2_1_14_2","first-page":"537","article-title":"Burkitt's lymphoma","volume":"1","author":"\u00c7avdar AO","year":"1971","journal-title":"Turkish J Cancer"},{"key":"e_1_2_1_15_2","first-page":"191","article-title":"Treatment of pediatric non Hodgkin's Lymphoma","volume":"10","author":"\u00c7avdar AO","year":"1988","journal-title":"Folia Oncol"},{"key":"e_1_2_1_16_2","unstructured":"UlukutluL Sa\u01e7lamerL YildizI T\u00fcz\u00fcnerN et al.:Results of chemotherapy in Burkitt's lymphoma. In Berkarda B Kuemmerle HP (eds): \u201cantimicrobial and Anti\u2010Cancer Chemotherapy.\u201d1987 Vol. 1. pp.637\u2013639."},{"key":"e_1_2_1_17_2","volume-title":"Histopathological Definition of Burkitt's Tumor","author":"Berard C","year":"1969"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870115)59:2<305::AID-CNCR2820590223>3.0.CO;2-H"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-230X(08)60470-4"},{"key":"e_1_2_1_19_3","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1182\/blood.V75.9.1848.1848","article-title":"Localization of break points by polymerase chain reactions in Burkitt's Lymphoma with 8:14 translocations","volume":"75","author":"Shiramizu B","year":"1990","journal-title":"Blood"},{"key":"e_1_2_1_20_2","doi-asserted-by":"crossref","first-page":"4084","DOI":"10.1128\/jvi.64.9.4084-4092.1990","article-title":"Epstein Barr Virus types 1 and 2 differ in their EBNA\u20103A, EBNA 3b, and EBNA\u20103C genes","volume":"64","author":"Sample J","year":"1990","journal-title":"J Virol"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1136\/adc.61.10.1013"},{"key":"e_1_2_1_22_2","first-page":"577","volume-title":"Hematology\/Oncology Clinics of North America","author":"Magrath IT","year":"1987"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1982.107"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840415)53:8<1777::AID-CNCR2820530828>3.0.CO;2-7"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-198623000-00003"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1987.tb02258.x"},{"key":"e_1_2_1_27_2","first-page":"1410","article-title":"Editorial: Short\u2010Term intensive therapy for childhood non\u2010Hodgkin Lymphoma","year":"1987","journal-title":"Lancet"},{"key":"e_1_2_1_28_2","first-page":"399","article-title":"Immunosuppression in Burkitt's Lymphoma II","volume":"17","author":"Magrath IT","year":"1976","journal-title":"Peripheral blood lymphocyte populations related to clinical status. Int J Cancer"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910170404"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.3109\/10408368709105879"}],"container-title":["Medical and Pediatric Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmpo.2950210108","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mpo.2950210108","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T19:55:30Z","timestamp":1698177330000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mpo.2950210108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1993,1]]}},"alternative-id":["10.1002\/mpo.2950210108"],"URL":"https:\/\/doi.org\/10.1002\/mpo.2950210108","archive":["Portico"],"relation":{},"ISSN":["0098-1532","1096-911X"],"issn-type":[{"value":"0098-1532","type":"print"},{"value":"1096-911X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,1]]}}}