{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,28]],"date-time":"2023-10-28T19:24:56Z","timestamp":1698521096393},"reference-count":29,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":4948,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Myelodisplastic syndromes (MDS) in childhood deserve a negative prognosis even though disease\u2010free survival has been obtained in 20% of cases by using aggressive chemotherapy. We describe three children with refractory anemia with excess of blasts in transformation (RAEB\u2010T) who underwent bone marrow transplantation (BMT). We also reviewed 21 additional cases (median age was 8 years) with primary MDS recently reported in the literature with the aim of clarifying the role of BMT in treating these patients.<\/jats:p><jats:p>Twelve of the 24 children were long\u2010term survivors and free from disease at a median time of 1,320 days (range 302\u20132,340). There were five relapses, two graft failures, two early deaths (one VOD, one severe GVHD), and three late deaths (two respiratory diseases, one severe GVHD). We didn't find any correlation between karyotype and outcome.<\/jats:p><jats:p>In conclusion, so far BMT seems to be the most valid treatment of childhood primary MDS. However, since the major causes of failure were regimen\u2010related toxicity or recurrence of the disease after BMT, it must be pointed out that, when a compatible donor even unrelated is available, BMT for childhood MDS should be given as soon as possible or at any rate prior to blastic crisis. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mpo.2950210109","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T19:06:14Z","timestamp":1171998374000},"page":"43-48","source":"Crossref","is-referenced-by-count":9,"title":["Allogeneic bone marrow transplantation for myelodysplastic syndromes of childhood: Report of three children with refractory anemia with excess of blasts in transformation and review of the literature"],"prefix":"10.1002","volume":"21","author":[{"given":"Cornelio","family":"Uderzo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Locasciulli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo Cant\u00f9","family":"Rajnoldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruggero","family":"Mozzana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgio","family":"Lambertenghi\u2010Deliliers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Masera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(81)80761-5"},{"key":"e_1_2_1_3_2","first-page":"5","article-title":"Myelodysplastic syndromes in children: observations on five cases","volume":"71","author":"Cant\u00f9 Rajnoldi A","year":"1984","journal-title":"Eur Paediatr Haematol Oncol"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1985.3.7.982"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1986.tb07524.x"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1182\/blood.V69.1.92.92","article-title":"Treatment of preleukemic syndromes with marrow transplantation","volume":"69","author":"Appelbaum FR","year":"1987","journal-title":"Blood"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1987.5.11.1822"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1988.6.12.1851"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1988.tb07598.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-199021000-00012"},{"issue":"2","key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1182\/blood.V73.2.619.619","article-title":"Bone marrow transplantation for children with myelodysplastic syndromes","volume":"73","author":"Guinan EC","year":"1989","journal-title":"Blood"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1990.tb02558.x"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840040121"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198907000-00016"},{"key":"e_1_2_1_15_2","doi-asserted-by":"crossref","unstructured":"CreutzigU RitterJ RiehmH et al.:The childhood AML studies BFM\u201078 and 83: treatment results and risk factor analysis. 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(eds): \u201cacute Leukemias Haematology and Blood Transfusion.\u201d30:71\u201375 1987.","DOI":"10.1007\/978-3-642-71213-5_12"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-198612000-00006"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/274590a0"},{"key":"e_1_2_1_18_2","first-page":"503","article-title":"Ras mutations in myelodysplasia detected by amplification, oligogonudeotide hybridisation and transformation","volume":"2","author":"Padua RA","year":"1988","journal-title":"Leukemia"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1987.tb02318.x"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1985.tb02996.x"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1986.tb02927.x"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-198724000-00009"},{"key":"e_1_2_1_23_2","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1182\/blood.V71.3.703.703","article-title":"Randomized study of 13\u2010Cis retinoic acid vs placebo in the myelodysplastic disorders","volume":"71","author":"Koeffler HP","year":"1988","journal-title":"Blood"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V72.2.705.705"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198712173172501"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1987.00145a.x"},{"key":"e_1_2_1_27_2","first-page":"97","article-title":"Childhood monosomy 7 syndrome: clinical and in vitro studies","volume":"1","author":"Weiss K","year":"1987","journal-title":"Leukemia"},{"key":"e_1_2_1_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(85)80027-5"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1990.8.10.1707"},{"key":"e_1_2_1_30_2","first-page":"287","article-title":"The use of unrelated bone marrow donors in the treatment of patients with chronic myelogenous leukemia: experience of four marrow transplant centers","volume":"4","author":"Beatty PG","year":"1989","journal-title":"Bone Marrow Transplant"}],"container-title":["Medical and Pediatric Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmpo.2950210109","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mpo.2950210109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T19:55:34Z","timestamp":1698177334000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mpo.2950210109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1993,1]]}},"alternative-id":["10.1002\/mpo.2950210109"],"URL":"https:\/\/doi.org\/10.1002\/mpo.2950210109","archive":["Portico"],"relation":{},"ISSN":["0098-1532","1096-911X"],"issn-type":[{"value":"0098-1532","type":"print"},{"value":"1096-911X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,1]]}}}