{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T08:28:33Z","timestamp":1791102513070,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":4948,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We describe here the clinical and pathologic features associated with a specific translocation, t(2;13), in alveolar rhabdomyo\u2010sarcoma. Tumor specimens from 14 patients with a t(2;13)\u2010positive alveolar rhabdomyo\u2010sarcoma were studied for cytogenetic\u2010clinicopathologic correlations. Three patients had occult primary tumors; nine patients had primary tumors of the trunk (mediastinal, pelvic, or rectal). The presence of the t(2;13) was ascertained from examination of tumor involved bone marrow in ten patients who had widespread metastatic disease at the time of diagnosis. Marrow involvement was so extensive in three cases that they were initially diagnosed as acute leukemia. Response to therapy was poor, with only five patients achieving a complete response. Twelve patients have died of their disease at a median survival time of 6 months from diagnosis and one is living with recurrent disease; only one patient survives free of disease. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mpo.2950210202","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T19:04:17Z","timestamp":1171998257000},"page":"83-87","source":"Crossref","is-referenced-by-count":57,"title":["Alveolar rhabdomyosarcoma with the t(2;13): Cytogenetic findings and clinicopathologic correlations"],"prefix":"10.1002","volume":"21","author":[{"given":"Edwin C.","family":"Douglass","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David N.","family":"Shapiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Valentine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan T.","family":"Rowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Carroll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. Beverly","family":"Raney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdel H.","family":"Ragab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Abella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Parham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198809013190908"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900515)65:10<2172::AID-CNCR2820651003>3.0.CO;2-K"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1159\/000132861"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880115)61:2<209::AID-CNCR2820610202>3.0.CO;2-L"},{"key":"e_1_2_1_6_2","volume-title":"Soft Tissue Sarcomas","author":"Enzinger FM","year":"1988"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000132446"},{"key":"e_1_2_1_8_2","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1200\/JCO.1991.9.1.159","article-title":"Relationship of tumor cell ploidy to histologic subtype and treatment outcome in children and adolescents with unresectable rhabdomyosarcoma","volume":"9","author":"Shapiro DN","year":"1990","journal-title":"J Clin Oncol"},{"key":"e_1_2_1_9_2","first-page":"983","article-title":"Chromosomal analysis of sixteen human rhabdomyosarcomas","volume":"48","author":"Wang\u2010Wuu S","year":"1988","journal-title":"Cancer Res"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870030611"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1988.6.1.67"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1990.8.3.443"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950170108"},{"key":"e_1_2_1_14_2","unstructured":"MaurerHM GehanEA BeltangadyM et al:The Intergroup Rhabdomyosarcoma Study II: A final report. Cancer1990(in press)."},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00441819"},{"key":"e_1_2_1_16_2","first-page":"308","article-title":"Tissue culture as a diagnostic technique for soft\u2010Tissue sarcoma of childhood","volume":"108","author":"Garvin AJ","year":"1984","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_1_17_2","first-page":"208","article-title":"The in vitro growth, heterotransplantation, and differentiation of a human rhabdomyosarcoma cell line","volume":"125","author":"Garvin AJ","year":"1986","journal-title":"Am J Pathol"},{"key":"e_1_2_1_18_2","first-page":"345","article-title":"Alveolar rhabdomyosarcoma: A cytogenetic and correlated cytological and histological study","volume":"90","author":"Seidal T","year":"1982","journal-title":"Acta Pathol Microbiol Immunol Scand"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(86)90069-5"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1987.207"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(87)90201-9"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(87)90202-0"}],"container-title":["Medical and Pediatric Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmpo.2950210202","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mpo.2950210202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T03:31:56Z","timestamp":1698204716000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mpo.2950210202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1993,1]]}},"alternative-id":["10.1002\/mpo.2950210202"],"URL":"https:\/\/doi.org\/10.1002\/mpo.2950210202","archive":["Portico"],"relation":{},"ISSN":["0098-1532","1096-911X"],"issn-type":[{"value":"0098-1532","type":"print"},{"value":"1096-911X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,1]]}}}