{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T20:59:24Z","timestamp":1761512364267},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":4948,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>By combining three series of Scandinavian patients, we were able to compare the late testicular sequelae in 41 adult males whose therapy had included chemotherapy alone or chemotherapy with cranial irradiation without other radiotherapy for ALL in childhood. In multivariate analysis, cranial irradiation was associated with a decrease of 5.7 (95% confidence limits 1.5\u20139.9) cm (<jats:italic>P<\/jats:italic>= 0.010) in height, and a decrease of 4.8 (0.3\u20139.2) ml (<jats:italic>P<\/jats:italic>= 0.036) in testicle size. Cyclophosphamide was associated with increases of 8.2 (\u22120.5\u201316.9) (<jats:italic>P<\/jats:italic>= 0.065) and 3.9 (0.3\u20137.4) U\/L (<jats:italic>P<\/jats:italic>= 0.036) in serum FSH and LH concentrations, respectively. Of the 12 patients who had received both cranial irradiation and cyclophosphamide therapy, 4 (33%) had delayed pubertal development as compared with 1 (3.5%) of the other 29 patients (<jats:italic>P<\/jats:italic>= 0.008). Patients 12\u201316 years of age at diagnosis had larger testicles (<jats:italic>P<\/jats:italic>= 0.051) and higher testosterone concentrations (<jats:italic>P<\/jats:italic>= 0.026) than others. Neither sexual activity nor semen findings correlated with the preceding treatment. Our data indicate that prophylactic cranial irradiation may be associated with impaired growth and pubertal development in boys with ALL. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mpo.2950210207","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T19:04:17Z","timestamp":1171998257000},"page":"117-121","source":"Crossref","is-referenced-by-count":16,"title":["Prophylactic cranial irradiation increases the risk of testicular damage in adult males surviving all in childhood"],"prefix":"10.1002","volume":"21","author":[{"given":"Martti A.","family":"Siimes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sverre O.","family":"Lie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ole","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ildiko","family":"Marky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jukka","family":"Rautonen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Hertz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(88)80218-X"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1989.7.3.304"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950160404"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-7372(80)80028-4"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)91442-3"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0277-5379(90)90623-2"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198907203210303"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1981.tb07176.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1987.tb10565.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.0954-6820.1952.tb13395.x","article-title":"Clinical measurements of the testes in boys and men","volume":"266","author":"Hansen PF","year":"1952","journal-title":"Acta Med Scand Suppl"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-70-1-107"},{"key":"e_1_2_1_13_2","volume-title":"WHO laboratory manual for the examination of human semen and semen\u2010Cervical mucus interaction","author":"World Health Organization","year":"1987"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900315)65:6<1303::AID-CNCR2820650608>3.0.CO;2-D"},{"key":"e_1_2_1_15_2","first-page":"61","article-title":"Testicular volume during adolescence: Cross\u2010Sectional and longitudinal studies","volume":"29","author":"Zachmann M","year":"1974","journal-title":"Helv Paediatr Acta"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1990.8.12.1981"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000421-198504000-00014"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820201)49:3<418::AID-CNCR2820490304>3.0.CO;2-A"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1981.03310380027020"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0447.1990.tb03055.x"}],"container-title":["Medical and Pediatric Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmpo.2950210207","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mpo.2950210207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,11]],"date-time":"2024-02-11T03:07:22Z","timestamp":1707620842000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mpo.2950210207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1993,1]]}},"alternative-id":["10.1002\/mpo.2950210207"],"URL":"https:\/\/doi.org\/10.1002\/mpo.2950210207","archive":["Portico"],"relation":{},"ISSN":["0098-1532","1096-911X"],"issn-type":[{"value":"0098-1532","type":"print"},{"value":"1096-911X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,1]]}}}