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We report the dramatic response to carboplatin in a 10\u2010year\u2010old girl with NF\u20101 and a progressive optic pathway tumor. Tumor shrinkage was accompanied by striking improvement in visual fields, return of color discrimination, and marked improvement in visual acuity. No significant toxicity was observed. One year following completion of chemotherapy the glioma remains as small or smaller than it was at the conclusion of therapy, and there has been no deterioration of vision. Carboplatin is a promising agent for the treatment of optic pathway tumors in children with NF\u20101. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mpo.2950210914","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T18:54:34Z","timestamp":1171997674000},"page":"680-684","source":"Crossref","is-referenced-by-count":9,"title":["Carboplatin\u2010induced regression of an optic pathway tumor in a child with neurofibromatosis"],"prefix":"10.1002","volume":"21","author":[{"given":"Joel","family":"Charrow","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Listernick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark J.","family":"Greenwald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lakshmi","family":"Das","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Ann","family":"Radkowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(84)34217-8"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(89)80137-4"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1985.63.6.0862"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410230113"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1991.74.5.0701"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1987.5.3.459"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1991.9.5.860"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19870301)59:5<1000::AID-CNCR2820590525>3.0.CO;2-N"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(82)34650-3"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1227\/00006123-197906000-00006"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1988.68.1.0085"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.73.12.967"},{"key":"e_1_2_1_14_2","first-page":"201","article-title":"Isolated optic nerve gliomas in children with and without neurofibromatosis","volume":"1","author":"Duffner PK","year":"1988","journal-title":"Neurofibromatosis"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198906000-00001"},{"key":"e_1_2_1_16_2","first-page":"393","article-title":"Chiasmatic gliomas of childhood. 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