{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:08:05Z","timestamp":1761894485020},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":4583,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[1994,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Children with cancer represent a high\u2010risk group for protein\u2010energy malnutrition due to side effects associated with treatment. Assessment of nutritional status at the time of diagnosis and during treatment is, therefore, essential for planning nutritional intervention. We studied the nutritional status of 25 children with leukemia [9 newly diagnosed\/relapsed (D\/R) leukemic patients and 16 children with leukemia in remission (REM)], Plasma proteins (prealbumin, PA; albumin, Alb; transferrin, Tr; retinol\u2010binding protein, RBP) and acute phase\u2010reactant proteins (\u03b1<jats:sub>1<\/jats:sub>\u2010acid glycoprotein, AGP; C\u2010reactive protein, CRP; ceruloplasmin, CER) were measured by radial immunodiffusion. Results show that there were no significant deficits in anthropometric measurements among leukemic children. In contrast, the mean levels of all plasma proteins, especially PA (<jats:italic>P<\/jats:italic> &lt; 0.005), were significantly lower in the D\/R group than in the REM group. All D\/R children, compared to 59% of those in remission, had PA levels &lt; 20 mg\/dl. Only the D\/R group had abnormal levels of RBP, Tr, and Alb. Children who were treated with prednisone had significantly higher mean levels of PA, RBP, and AGP than those who were not receiving prednisone. The mean levels of acute phase\u2010reactant proteins in these leukemic children were comparable to those of healthy children. We conclude that mild\/moderate malnutrition is common in leukemic patients at D\/R and that PA seems to be the most sensitive indicator of visceral protein Status. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mpo.2950220202","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T19:16:44Z","timestamp":1171999004000},"page":"73-77","source":"Crossref","is-referenced-by-count":29,"title":["Nutritional status of children with leukemia"],"prefix":"10.1002","volume":"22","author":[{"given":"Lolie C.","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Solo","family":"Kuvibidila","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael","family":"Ducos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. P.","family":"Warrier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197905)43:5 <2036::AID-CNCR2820430712>3.0.CO;2-7"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197905)43:5 <2065::AID-CNCR2820430714>3.0.CO;2-1"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1093\/ajcn\/38.3.445","article-title":"Effectiveness of central parenteral nutrition versus peripheral parenteral nutrition plus enteral nutrition in reversing protein\u2010energy malnutrition in children with advanced neuroblastoma and Wilm's tumor; a prospective randomized study","volume":"38","author":"Rickard KA","year":"1983","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-197912000-00018"},{"key":"e_1_2_1_6_2","first-page":"592","article-title":"Tumor necrosis factor in children with malignancies","volume":"50","author":"Saarinen UM","year":"1990","journal-title":"Cancer Res"},{"key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1093\/ajcn\/35.6.1490","article-title":"Enteral nutrition by nasogastric tube in adult patients treated with intensive chemotherapy for acute leukemia","volume":"35","author":"deVries EGE","year":"1982","journal-title":"Am J Clin Nutr"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(75)90379-4"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00454030"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1177\/0148607183007002151"},{"key":"e_1_2_1_11_2","unstructured":"World Health Organization: \u201cMeasuring Change in Nutritional Status.\u201d World Health Organization1983 pp.12\u201313."},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/34.11.2530"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/26.9.912"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/32.3.607"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/34.11.2540"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0019-2791(65)90004-2"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.4.5936.88"},{"key":"e_1_2_1_18_2","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1093\/clinchem\/30.8.1286","article-title":"Assessment of protein\u2010calorie malnutrition","volume":"30","author":"Haider M","year":"1984","journal-title":"Clin Chem"},{"key":"e_1_2_1_19_2","first-page":"339","article-title":"Bases m\u00e9thodologiques: Prot\u00e9ines de la r\u00e9action inflammatoire. Notion du profil prot\u00e9ique","volume":"39","author":"Engler R","year":"1984","journal-title":"P\u00e9diatrie"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1012232"},{"key":"e_1_2_1_21_2","first-page":"373","article-title":"Methods for the study of acute phase reactant proteins","volume":"163","author":"Colowick SP","year":"1988","journal-title":"Methods Enzymol"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-26-7-715"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(77)90013-0"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.1984.10720048"},{"key":"e_1_2_1_25_2","first-page":"1107","article-title":"A study of the nutritional status of pediatric cancer patients","volume":"135","author":"Donaldson SS","year":"1981","journal-title":"Am J Dis Child"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.13.3.225"},{"key":"e_1_2_1_27_2","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1093\/ajcn\/33.4.794","article-title":"Plasma thyroxine\u2010binding prealbumin as an index of mild protein energy malnutrition in Nigerian children","volume":"33","author":"Ogunshina S","year":"1980","journal-title":"Am J Clin Nutr"},{"issue":"5","key":"e_1_2_1_28_2","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/S0002-8223(21)02227-6","article-title":"Use of retinol\u2010binding protein and prealbumin as indicators of the response to nutrition therapy","volume":"89","author":"Winkler MF","year":"1989","journal-title":"J Am Diet Assoc"},{"key":"e_1_2_1_29_2","doi-asserted-by":"publisher","DOI":"10.1177\/0148607189013006596"},{"key":"e_1_2_1_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197905)43:5 <2030::AID-CNCR2820430711>3.0.CO;2-S"}],"container-title":["Medical and Pediatric Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmpo.2950220202","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mpo.2950220202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T14:22:26Z","timestamp":1698157346000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mpo.2950220202"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,1]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1994,1]]}},"alternative-id":["10.1002\/mpo.2950220202"],"URL":"https:\/\/doi.org\/10.1002\/mpo.2950220202","archive":["Portico"],"relation":{},"ISSN":["0098-1532","1096-911X"],"issn-type":[{"value":"0098-1532","type":"print"},{"value":"1096-911X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,1]]}}}