{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T09:11:11Z","timestamp":1698225071350},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":4583,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[1994,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Isolated organ perfusion is attractive for regional high\u2010dose chemotherapy because of its advantage to reduce whole body toxicity. Intraoperative hyperthermic isolated perfusion procedures involving a heart\u2010lung machine have been developed, but repeated treatments carry a high risk of vessel and tissue damage. Therefore, a study of isolated hyperthermic limb perfusion in four dogs was conducted using a balloon\u2010occlusion technique including a hyperthermia unit, two low\u2010flow rotary pumps, a bubble oxygenator, and two polyurethane balloon catheters. After 15 min infusion of cisplatinum the concentrations of serum platinum (Pt) in the isolated limb and in the whole body were measured by atomic absorption Spectroscopy. Regional exposure to Pt was more than 10\u2010fold higher than systemic exposure. After 60 min isolated limb perfusion, the area under the curve (AUC) of Pt concentrations in the isolated limb showed values between 767.4 and 1055.6 \u03bcg\/l \u00d7 60 min, whereas in the whole body values between 59.8 and 75.9 \u03bcg\/l \u00d7 60 min were obtained. Repeated isolated limb perfusions with the balloon\u2010occlusion technique were performed in three dogs without systemic side effects. This model of regional chemotherapy may be useful for preoperative chemotherapy in malignant tumors of the limbs. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mpo.2950220608","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T19:11:11Z","timestamp":1171998671000},"page":"393-397","source":"Crossref","is-referenced-by-count":0,"title":["Hyperthermic isolated limb perfusion with Cis\u2010diamminedichloro\u2010platinum. II. An experimental study in dogs with a balloon\u2010occlusion technique for repeated high\u2010dose treatment"],"prefix":"10.1002","volume":"22","author":[{"given":"R.","family":"Wessalowski","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Wilhelm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Torsello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Sager","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"G\u00fcttler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"J\u00fcrgens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"G\u00f6bel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1159\/000215480"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840915)54:1 <1226::AID-CNCR2820541321>3.0.CO;2-A"},{"key":"e_1_2_1_4_2","first-page":"602","article-title":"A silicone rubber atrial catheter for prolonged parenteral alimentation","volume":"136","author":"Broviac JW","year":"1973","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_1_5_2","first-page":"264","volume-title":"Recent results in cancer therapy","author":"Busse O","year":"1983"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1159\/000226433"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000429197"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/3.suppl_2.S71"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(80)90472-6"},{"key":"e_1_2_1_10_2","unstructured":"DeutschleR DohseW:Studie zur toxizit\u00e4t von 1 2\u2010dichlor\u00e4than. 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