{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T11:15:33Z","timestamp":1698146133738},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":4583,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[1994,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We retrospectively analyzed the ocular findings after polychemotherapy including intrathecal methotrexate, systemic corticosteroids, and prophylactic cranial irradiation in children with acute lymphoblastic leukemia (n = 16) and non\u2010Hodgkin's lymphoma (n = 2). After a median surveillance time of 4.1 years, asymptomatic ocular abnormalities were observed in 83% of the patients: 7\/18 had a decreased tear formation, 5\/17 had an opacity of the vitreous body, and 13\/18 had an opacity of the lens. It was not possible to determine retrospectively which therapy caused a particular effect. A comparison of the 2 irradiation techniques (with and without blocking of the lacrimal glands) showed that in 5\/7 children who developed a reduced eye secretion, the lacrimal glands are within the treatment volume. Therefore, the reduced eye secretion is most likely radiation\u2010induced. Whereas the opacities of the vitreous body were caused by thrombopenia and bleeding during the course of disease, corticoid therapy might have contributed to the lens opacities. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mpo.2950230405","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T19:09:02Z","timestamp":1171998542000},"page":"344-349","source":"Crossref","is-referenced-by-count":5,"title":["Ocular sequelae of multimodal therapy of hematologic malignancies in children"],"prefix":"10.1002","volume":"23","author":[{"given":"B.","family":"Pakisch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Langmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Langmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Slavc","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Poier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Urban","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Poschauko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Lackner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Knoblauch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Leitner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. J.","family":"Dornbusch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"St\u00fccklschweiger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Raith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Hackl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(76)90042-0"},{"key":"e_1_2_1_3_2","first-page":"705","volume-title":"Strahlentherapie, Radiologische Onkologie","author":"Mussoff K","year":"1979"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-8140(87)80005-1"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(92)90559-Z"},{"key":"e_1_2_1_6_2","first-page":"271","volume-title":"Medizinische Physik","author":"St\u00fccklschweiger G","year":"1988"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-74643-7_81"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1026780"},{"key":"e_1_2_1_9_2","unstructured":"GardnerH MutzI UrbanC Gr\u00fcnmayerER AussererB TulzerW: Modified BFM treatment in childhood acute lymphoblastic leukemia (ALL)\u2014Results of the Austrian\u2010A\u201084 study.Proc 4th Int Symp Ther Acute Leukp.404 1987."},{"key":"e_1_2_1_10_2","first-page":"24","volume-title":"The Crystalline Lens. Atlas of Diseases of the Anterior Segment of the Eye","author":"Donaldson DD","year":"1976"},{"key":"e_1_2_1_11_2","first-page":"65","volume-title":"Pediatric Ophthalmology","author":"Moor A","year":"1990"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860815)58:4<963::AID-CNCR2820580427>3.0.CO;2-C"},{"key":"e_1_2_1_13_2","first-page":"173","volume-title":"Radiation Oncology","author":"Moss WT","year":"1989"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-08-027176-7.50007-X"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(83)90225-0"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197610)38:4<1744::AID-CNCR2820380449>3.0.CO;2-3"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1952.01700030058006"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1971.tb05936.x"},{"key":"e_1_2_1_19_2","first-page":"683","article-title":"Zur Frage der Strahlenkatarakt bei Betabestrahlung des vorderen Augenabschnittes","volume":"150","author":"Lommatsch P","year":"1967","journal-title":"Klin Monatsbl Augenheilkd"},{"key":"e_1_2_1_20_2","first-page":"759","article-title":"A clinical study of radiation cataracts and the relationship to dose","volume":"77","author":"Merriam GR","year":"1957","journal-title":"Am J Roentgenol Radiat Ther"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1159\/000392817"},{"key":"e_1_2_1_22_2","first-page":"98","volume-title":"Retinoblastoma","author":"Schipper J","year":"1980"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1148\/120.3.673"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1177\/000992287701600810"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(88)33198-2"},{"issue":"2","key":"e_1_2_1_26_2","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1182\/blood.V61.2.297.297","article-title":"Efficacy and morbidity of central nervous system \u201cprophylaxis\u201d in childhood acute lymphoblastic leukemia: Eight years' experience with cranial irradiation and intrathecal methotrexate","volume":"61","author":"Inati A","year":"1983","journal-title":"Blood"}],"container-title":["Medical and Pediatric Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmpo.2950230405","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mpo.2950230405","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T01:32:10Z","timestamp":1698111130000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mpo.2950230405"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,1]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1994,1]]}},"alternative-id":["10.1002\/mpo.2950230405"],"URL":"https:\/\/doi.org\/10.1002\/mpo.2950230405","archive":["Portico"],"relation":{},"ISSN":["0098-1532","1096-911X"],"issn-type":[{"value":"0098-1532","type":"print"},{"value":"1096-911X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,1]]}}}