{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T06:01:18Z","timestamp":1757311278832},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":4583,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[1994,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>To evaluate the clinical characteristics and treatment outcome of childhood non\u2010Hodgkin lymphoma (NHL) cases with bone marrow involvement, we studied 13 lymphoblastic, 15 small noncleaved cell, and 8 large cell cases with tumor cells in their marrow. They represented 16%, 11%, and 9% of consecutive NHL cases with these respective histologic subtypes. The treatment outcome differed significantly according to histologic subtype\u2014the 5\u2010year event\u2010free survivals (EFS \u00b1 SE) for large cell NHL, small non\u2010cleaved cell NHL, and lymphoblastic NHL cases were 11 \u00b1 8%, 40 \u00b1 20%, and 62 \u00b1 15%, respectively. Increased serum lactate dehydrogenase (LDH) levels (&gt;500 U\/L) were associated with a poorer EFS (5\u2010year EFS, 0% vs. 50 \u00b1 10%; <jats:italic>P<\/jats:italic> &lt; 0.001). Children \u2a7d5 years of age had a poorer EFS survival than older children (5\u2010year EFS, 14 \u00b1 9% vs. 44 \u00b1 10%; <jats:italic>P<\/jats:italic> = 0.03). The degree of bone marrow involvement (&lt;5% vs. \u2a7e5%) and race were not significantly associated with treatment outcome. Although intensive chemotherapy has substantially improved survival for patients with advanced stage lymphoblastic or small noncleaved cell lymphoma, patients with large cell NHL and associated marrow involvement continue to have a dismal outcome and require novel or more intensive therapy. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mpo.2950230406","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T19:09:02Z","timestamp":1171998542000},"page":"350-353","source":"Crossref","is-referenced-by-count":8,"title":["Factors contributing to the prognostic significance of bone marrow involvement in childhood non\u2010Hodgkin lymphoma"],"prefix":"10.1002","volume":"23","author":[{"given":"J. T.","family":"Sandlund","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.\u2010S.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Ayers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. M.","family":"Santana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. L.","family":"Furman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Mahmoud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. W.","family":"Berard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. E.","family":"Hutchison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. M.","family":"Crist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Rafferty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.\u2010H.","family":"Pui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1989.7.2.186"},{"key":"e_1_2_1_3_2","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1182\/blood.V63.5.1102.1102","article-title":"An effective therapy for both undifferentiated (including Burkitts) lymphomas and lymphoblastic lymphomas in children and young adults","volume":"63","author":"Magrath IT","year":"1984","journal-title":"Blood"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820515)49:10<2112::AID-CNCR2820491024>3.0.CO;2-2"},{"key":"e_1_2_1_5_2","first-page":"332","article-title":"Classification, staging and end results of treatment of childhood non\u2010Hodgkin's lymphomas: Dissimilarities from lymphoma in adults","volume":"7","author":"Murphy SB","year":"1980","journal-title":"Semin Oncol"},{"key":"e_1_2_1_6_2","first-page":"187","article-title":"MACOP\u2010B treatment in children and adolescents with advanced diffuse large\u2010cell non\u2010Hodgkin's lymphoma","volume":"7","author":"Santana VM","year":"1993","journal-title":"Leukemia"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"key":"e_1_2_1_8_2","first-page":"553","article-title":"A class of rank test procedures for censored survival data","volume":"69","author":"Harrington DP","year":"1982","journal-title":"JASA"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1988.10478691"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198303103081003"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950170512"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850115)55:2<323::AID-CNCR2820550204>3.0.CO;2-9"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1988.6.1.26"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19821101)50:9<1695::AID-CNCR2820500907>3.0.CO;2-H"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19830701)52:1<39::AID-CNCR2820520109>3.0.CO;2-S"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.10.2471.2471"},{"key":"e_1_2_1_17_2","first-page":"340","article-title":"on behalf of SFOP: High survival rate of childhood B\u2010cell lymphoma and leukemia (ALL) as result of the LMB 89 Protocol of the SFOP","volume":"11","author":"Patte C","year":"1992","journal-title":"Proc ASCO"}],"container-title":["Medical and Pediatric Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmpo.2950230406","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mpo.2950230406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T01:32:14Z","timestamp":1698111134000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mpo.2950230406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,1]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1994,1]]}},"alternative-id":["10.1002\/mpo.2950230406"],"URL":"https:\/\/doi.org\/10.1002\/mpo.2950230406","archive":["Portico"],"relation":{},"ISSN":["0098-1532","1096-911X"],"issn-type":[{"value":"0098-1532","type":"print"},{"value":"1096-911X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,1]]}}}