{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T21:45:57Z","timestamp":1767649557664},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":4583,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[1994,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neoplasias of the monocyte\/macrophage system are rare. They include malignant histocytosis, sarcomas of dendritic cells, and possibly a malignant form of Langerhans cell histiocytosis. Characterization of all these neoplasms can be easily done along the lines which have been developed for the derivation of the normal cellular counterparts. The possibility of a malignant transformation of the cells of the monocyte\/macrophage system is suggested by the fact that all members of this system can undergo mitotic division. The most controversial among the different entities is malignant histiocytosis, which has proved to be anaplastic large cell lymphoma (ALCL) with Ki1 expression in most cases. The few cases of true malignant histocytosis may or may not express the Ki1 antigen. Sarcomas of dendritic cells have been related mainly to interdigitating or follicular dendritic cells. Prognosis of follicular dendritic cell sarcoma is probably more favorable than that of interdigitating cell sarcoma. Besides these more frequent subtypes, a sarcoma of the sinus lining cells can be separated which represents a low\u2010grade malignant neoplasm. All cases encountered so far were associated with a protracted clinical course, albeit multiple recurrences. A distinctly more aggressive behavior is encountered in those cases which have been identified as a malignant form of Langerhans cell histiocytosis. However, the issue of this particular form of histiocytic disorder is still unsettled. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mpo.2950230510","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T19:08:59Z","timestamp":1171998539000},"page":"444-451","source":"Crossref","is-referenced-by-count":12,"title":["Monocyte\/macrophage system and malignancies"],"prefix":"10.1002","volume":"23","author":[{"given":"Dietmar","family":"Schmidt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"306","article-title":"Detection of a monocyte\/macrophagte differentiation antigen in routinely processed paraffin\u2010embedded tissues by monoclonal antibody Ki\u2010MlP","volume":"65","author":"Radzun HJ","year":"1991","journal-title":"Lab Invest"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.42.4.414"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/35.11.3309045"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1146\/annurev.iy.09.040191.001415","article-title":"The dendritic cell system and its role in immunogenicity","volume":"9","author":"Steinmann RM","year":"1991","journal-title":"Annu Rev Immunol"},{"key":"e_1_2_1_6_2","series-title":"1st series, fasc 8","volume-title":"Atlas of Tumor Pathology","author":"Rappaport H","year":"1966"},{"key":"e_1_2_1_7_2","first-page":"369","article-title":"Frequent immunoglobulin and T\u2010cell receptor gene rearrangements in \u201chistiocytic\u201d neoplasms","volume":"121","author":"Weiss LM","year":"1985","journal-title":"Am J Pathol"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1025309"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900801)66:3<530::AID-CNCR2820660321>3.0.CO;2-6"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/299065a0"},{"key":"e_1_2_1_11_2","doi-asserted-by":"crossref","first-page":"1678","DOI":"10.1182\/blood.V74.5.1678.1678","article-title":"Ber H2: A new anti\u2010Ki\u20101 (CD30) monoclonal antibody directed at a formol\u2010resistant epitope","volume":"74","author":"Schwarting R","year":"1989","journal-title":"Blood"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19901215)66:12<2547::AID-CNCR2820661217>3.0.CO;2-6"},{"key":"e_1_2_1_13_2","first-page":"1009","article-title":"Malignant histiocytosis. 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