{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T13:22:01Z","timestamp":1700400121798},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":4583,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[1994,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>(1) <jats:italic>Purpose:<\/jats:italic> To assess the efficacy of a chemotherapy\u2010only regimen in pediatric patients with disseminated nonlymphoblastic lymphoma and acute B\u2010cell leukemia (B\u2010ALL).<\/jats:p><jats:p>(2) <jats:italic>Patients and Methods:<\/jats:italic> Sixty\u2010eight eligible patients with previously untreated disseminated non\u2010lymphoblastic lymphoma were enrolled on a Childrens Cancer Group study. Therapy included cycles of chemotherapy, systemic and intrathecal (IT), ever 3 weeks for a total maximal duration of 57 weeks. Fifty\u2010five patients had small non\u2010cleaved cell lymphoma (SNCCL) and 13 had diffuse large cell lymphoma (DLCL). Forty\u2010seven were stage III, six were stage IV, and 15 had B\u2010ALL; 13 had central nervous system (CNS) involvement.<\/jats:p><jats:p>(3) <jats:italic>Results:<\/jats:italic> Four year event\u2010free survival (EFS) was 53% (SE \u00b1 12%). Stage III SNCCL patients with LDH &lt; 500 IU\/L achieved an improved EFS compared to other SNCCL patients (86% vs. 42% 4 year EFS, <jats:italic>P<\/jats:italic> = .072). The primary site of failure for advanced stage SNCCL patients was the CNS. All Ki\u20101\u2010positive DLCL patients relapsed. Patterns of failure, time to relapse, and outcome following relapse differed between SNCCL and DLCL patients.<\/jats:p><jats:p>(4) <jats:italic>Conclusions:<\/jats:italic> Advanced stage SNCCL requires better CNS\u2010directed chemotherapy to reduce the CNS failure rate; however, the achievement of durable disease\u2010free survival in four of 11 patients with CNS disease without use of cranial irradiation suggests merit for further evaluation of chemotherapy\u2010only strategies. DLCL patients do not need intensive CNS\u2010directed chemotherapy. \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mpo.2950230602","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T19:05:11Z","timestamp":1171998311000},"page":"453-463","source":"Crossref","is-referenced-by-count":18,"title":["Disseminated nonlymphoblastic lymphoma of childhood: A childrens cancer group study, CCG\u2010552"],"prefix":"10.1002","volume":"23","author":[{"given":"Jonathan L.","family":"Finlay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James R.","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony J.","family":"Cecalupo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond 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