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Autopsy revealed a large intraventricular lesion with mixed germ cell tumor elements, but no other evidence of malignancy was found. This case represents the first report of isolated CNS metastasis of malignant germ cell tumor in a child in apparent remission without evidence of advanced or recurrent disease in other sites. It is possible that the aggressive chemotherapy used resulted in a change in the natural history of this disorder. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mpo.2950240108","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T19:26:10Z","timestamp":1171999570000},"page":"36-39","source":"Crossref","is-referenced-by-count":6,"title":["Isolated CNS metastasis as the first site of recurrence in a child with germ cell tumor of the mediastinum"],"prefix":"10.1002","volume":"24","author":[{"given":"Roger L.","family":"Berkow","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David R.","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"3","volume-title":"Principles and Practice of Pediatric Oncology","author":"Robison LL","year":"1993"},{"key":"e_1_2_1_3_2","first-page":"867","volume-title":"Principles and Practice of Pediatric Oncology","author":"Ablin A","year":"1993"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900501)63:9<1657::AID-CNCR2820630902>3.0.CO;2-8"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.2950190405"},{"key":"e_1_2_1_6_2","doi-asserted-by":"crossref","first-page":"1782","DOI":"10.1200\/JCO.1991.9.10.1782","article-title":"Results of treatment of malignant germ cell tumors in 93 children: A report from the Children's Cancer Study Group","volume":"9","author":"Ablin AR","year":"1991","journal-title":"J Clin Oncol"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19921115)70:10<2568::AID-CNCR2820701028>3.0.CO;2-1"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-4295(76)90374-5"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-198911000-00021"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1200\/JCO.1984.2.12.1397","article-title":"Brain metastases and testicular tumors: Need for aggressive therapy","volume":"2","author":"Lester SG","year":"1984","journal-title":"J Clin Oncol"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197910)44:4<1514::AID-CNCR2820440450>3.0.CO;2-4"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19820101)49:1<12::AID-CNCR2820490104>3.0.CO;2-Q"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19811015)48:8<1890::AID-CNCR2820480830>3.0.CO;2-D"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19811201)48:11<2371::AID-CNCR2820481106>3.0.CO;2-#"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00973340"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19841015)54:8<1687::AID-CNCR2820540833>3.0.CO;2-U"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19861215)58:12<2579::AID-CNCR2820581204>3.0.CO;2-V"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19931001)72:7<2182::AID-CNCR2820720719>3.0.CO;2-P"},{"key":"e_1_2_1_19_2","first-page":"358","article-title":"Primary extracranial neuroblastoma with central nervous system metastases. 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