{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:16:08Z","timestamp":1761822968280},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":4218,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[1995,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A case of primary intracranial germ cell tumour is reported in a 5\u2010year\u2010old Chinese boy who presented with symptoms and signs of increased intracranial pressure. Computed tomography (CT) scan of the brain revealed a multicystic tumour over the pineal region. Stereotactic biopsy yielded enteric epithelium and isolated cells with hyperchromatic nuclei and high nuclear\u2010to\u2010cytoplasmic ratio, suggesting the diagnosis of an immature teratoma. Grossly elevated serum and cerebrospinal fluid (CSF) levels of \u03b1\u2010fetoprotein and mildly elevated levels of \u03b2 human chorionic gonadotrophin suggested the simultaneous presence of embryonal tissues. Combination chemotherapy with cisplatin, etoposide, and bleomycin resulted in a gradual but complete normalisation of the serum and CSF tumour markers. Paradoxically, the patient's consciousness deteriorated and repeat CT scan after 3 months of treatment showed that the tumour was actually increasing in size. Complete surgical removal was attempted and histologic sections of the specimen revealed only mature teratomatous tissues. The child is now well and remains disease\u2010free with minimal left hemiparesis 12 months after completion of treatment. This case illustrates the importance of combined neoadjuvant chemotherapy and surgery in the management of intracranial non\u2010germinomatous germ cell tumour harbouring both germ cell and teratomatous components, while monitoring of both biochemical and radiological parameters are necessary in assessing the clinical behaviour of mixed germ cell tumours. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mpo.2950240112","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T19:26:10Z","timestamp":1171999570000},"page":"53-57","source":"Crossref","is-referenced-by-count":22,"title":["Paradoxical response of a pineal immature teratoma to combination chemotherapy"],"prefix":"10.1002","volume":"24","author":[{"given":"Anselm C. W.","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Godfrey C. F.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. F.","family":"Fung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Y.","family":"Leung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. L.","family":"Lau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19800415)45:8<2119::AID-CNCR2820450820>3.0.CO;2-J"},{"key":"e_1_2_1_3_2","first-page":"145","article-title":"Germ cell tumours","volume":"5","author":"Talerman A","year":"1985","journal-title":"Ann Pathol"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1991.00530180110026"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1980.53.2.0239"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840801)54:3<520::AID-CNCR2820540323>3.0.CO;2-E"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1159\/000120321"},{"key":"e_1_2_1_8_2","first-page":"113","article-title":"An operation for the removal of pineal tumors","volume":"33","author":"Dandy WE","year":"1921","journal-title":"Surg Gynecol Obstet"},{"key":"e_1_2_1_9_2","first-page":"869","article-title":"Pinealoma: a clinicopathological study of seven cases with a review of the literature","volume":"35","author":"Russell WO","year":"1943","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1948.5.3.0249"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(90)90396-2"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850601)55:11<2688::AID-CNCR2820551125>3.0.CO;2-H"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1987.67.1.0065"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860601)57:11<2108::AID-CNCR2820571103>3.0.CO;2-Z"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198309000-00016"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850301)55:5<932::AID-CNCR2820550504>3.0.CO;2-H"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.304.6839.1426"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.305.6844.52-a"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.1985.tb00021.x"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1985.63.3.0463"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1979.51.3.0368"}],"container-title":["Medical and Pediatric Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmpo.2950240112","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mpo.2950240112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T07:55:15Z","timestamp":1698306915000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mpo.2950240112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1995,1]]}},"alternative-id":["10.1002\/mpo.2950240112"],"URL":"https:\/\/doi.org\/10.1002\/mpo.2950240112","archive":["Portico"],"relation":{},"ISSN":["0098-1532","1096-911X"],"issn-type":[{"value":"0098-1532","type":"print"},{"value":"1096-911X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,1]]}}}