{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T12:12:13Z","timestamp":1754395933510},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":4159,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[1995,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Neuroblastoma is one of the most frequent solid tumors in childhood, rarely recurrent after five years from diagnosis. Cytomegalovirus (CMV), a major pathogen causing congenital birth defects and severe opportunistic diseases, has been shown to have teratogenic, immunodepressive and oncogenic properties.<\/jats:p><jats:p>The case of a girl with stage 45 neuroblastoma diagnosed at three months and relapsed as stage 4 five years later is reported. In both circumstances, active CMV infection was revealed by positive CMV\u2010specific IgM and IgA antibodies, CMV\u2010DNAemia and CMV culture.<\/jats:p><jats:p>At three months, the patient presented with subcutaneous nodules, hepatosplenomegaly and increased aminotransferase levels, and the opsoclonus\u2010myoclonus syndrome. Mental retardation developed later on. At 5 years, relapsed neuroblastoma was preceded by a mononucleosis\u2010like syndrome concomitant with active CMV infection and decreased levels of immune cells and natural killer activity.<\/jats:p><jats:p>Clinical, virologic, and immunologic findings suggest an immune\u2010mediated pathogenic role for CMV in this tumor. \u00a9 1995 Wi1ey\u2010Liss Inc.<\/jats:p>","DOI":"10.1002\/mpo.2950240311","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T19:24:34Z","timestamp":1171999474000},"page":"200-203","source":"Crossref","is-referenced-by-count":15,"title":["Cytomegalovirus\u2010associated stage 4S neuroblastoma relapsed stage 4"],"prefix":"10.1002","volume":"24","author":[{"given":"Giovanni","family":"Nigro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amalia","family":"Schiavetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James 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