{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T23:56:09Z","timestamp":1770508569281,"version":"3.49.0"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T00:00:00Z","timestamp":1153353600000},"content-version":"vor","delay-in-days":4098,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med. Pediatr. Oncol."],"published-print":{"date-parts":[[1995,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We describe the case of a 3\u2010year\u2010old girl who developed veno\u2010occlusive disease of the liver while receiving chemotherapy for parameningeal rhabdomyosarcoma. After suffering lethargy and oral mucosal bleeding for one day, the patient exhibited a sudden weight gain and refractoriness to platelet transfusions. Symptoms rapidly worsened with elevation of liver enzymes, bleeding diatheses, and respiratory failure. An ultrasound scan of the liver demonstrated reversed flow in the portal vein. Maximal supportive care, including tracheal intubation and mechanical ventilation, was required. The patient gradually recovered with no respiratory and minimal neurological sequelae. Veno\u2010occlusive disease of the liver should be considered in children receiving chemotherapy who develop weight gain, a sudden drop in platelet count and derangement of liver enzymes. Aggressive supportive measures should be instituted if necessary, as patients surviving the acute phase can expect to make a full recovery. \u00a9 1995 Wi1ey\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mpo.2950240513","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T19:23:49Z","timestamp":1171999429000},"page":"334-340","source":"Crossref","is-referenced-by-count":21,"title":["Veno\u2010occlusive Disease of the Liver After Chemotherapy for Rhabdomyosarcoma: Case Report With a Review of the Literature"],"prefix":"10.1002","volume":"24","author":[{"given":"Vikramjit S.","family":"Kanwar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Luiza C.","family":"Albuquerque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raul C.","family":"Ribeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William M.","family":"Kauffman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wayne L.","family":"Furman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"285","article-title":"Veno\u2010occlusive disease of liver with nonportal type of cirrhosis, occurring in Jamaica","volume":"57","author":"Bras G","year":"1954","journal-title":"Arch Pathol"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1921.02350170002001"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/22.1.22"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/S0016-5085(19)32476-X","article-title":"Hepatic veno\u2010occlusive disease in a renal transplant patient receiving azathioprine","volume":"69","author":"Marubbio AT","year":"1975","journal-title":"Gastroenterology"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-85-5-578"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.35.10.1086"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19831115)52:10<1803::AID-CNCR2820521007>3.0.CO;2-D"},{"key":"e_1_2_1_9_2","first-page":"76","article-title":"Chemotherapy\u2010induced hepatic veno\u2010occlusive disease (VOD). (Abstract)","volume":"2","author":"Callihan T","year":"1983","journal-title":"Proc Am Soc Clin Oncol"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19800515)45:10<2670::AID-CNCR2820451031>3.0.CO;2-L"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1990.8.9.1525"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1177\/028418518502600515"},{"key":"e_1_2_1_13_2","first-page":"316","article-title":"Severe liver toxicity in pre\u2010operative chemotherapy of SIOP 9 protocol. (Abstract)","volume":"17","author":"De Sio L","year":"1989","journal-title":"Med Pediatr Oncol"},{"key":"e_1_2_1_14_2","first-page":"317","article-title":"Hepatic toxicity compatible with veno\u2010occlusive disease (VOD) after actinomycin D in non\u2010irradiated Wilm's tumor. (Abstract)","volume":"17","author":"Oberlin O","year":"1989","journal-title":"Med Pediatr Oncol"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19880715)62:2<270::AID-CNCR2820620208>3.0.CO;2-B"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1991.9.2.268"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.3109\/08880018809031252"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199204000-00013"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-118-4-199302150-00003"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(18)30644-0"},{"key":"e_1_2_1_21_2","first-page":"255","article-title":"Pre\u2010treatment staging system for pediatric rhabdomyosarcoma patients","volume":"7","author":"Gehan E","year":"1988","journal-title":"Proc Am Soc Clin Oncol"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840040121"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(86)90266-4"},{"key":"e_1_2_1_24_2","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/0016-5085(80)90911-7","article-title":"An analysis of hepatic veno\u2010occlusive disease and centrilobular hepatic degeneration following bone marrow transplantation","volume":"79","author":"Schulman HM","year":"1980","journal-title":"Gastroenterology"},{"key":"e_1_2_1_25_2","first-page":"193a","article-title":"Procoagulant imbalance due to low levels of protein C in patients with veno\u2010occlusive disease (VOD) of the liver after marrow transplantation. (Abstract)","volume":"78","author":"Faioni EM","year":"1991","journal-title":"Blood"},{"key":"e_1_2_1_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91646-4"},{"key":"e_1_2_1_27_2","first-page":"721","article-title":"Doppler sonography: A noninvasive method for evaluation of hepatic veno\u2010occlusive disease","volume":"154","author":"Brown BP","year":"1990","journal-title":"Am J Radiol"},{"key":"e_1_2_1_28_2","first-page":"829","article-title":"Actinomycin\u2010D in childhood acute lymphocytic leukemia","volume":"62","author":"Green DM","year":"1978","journal-title":"Cancer Treat Rep"},{"key":"e_1_2_1_29_2","first-page":"197","article-title":"Hepatic veno\u2010occlusive diseaseliver toxicity syndrome after bone marrow transplantation","volume":"10","author":"Shulman HM","year":"1992","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_1_30_2","first-page":"65","article-title":"Hepatotoxicity of chemotherapeutic agents","volume":"9","author":"Perry MC","year":"1982","journal-title":"Semin Oncol"},{"key":"e_1_2_1_31_2","first-page":"1773","article-title":"Thrombocytopenia in venocclusive disease after bone marrow transplantation or chemotherapy","volume":"6","author":"Andreu BRG","year":"1986","journal-title":"Blood"},{"key":"e_1_2_1_32_2","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1182\/blood.V75.4.1011.1011","article-title":"Increased serum levels of tumor necrosis factor\u2010\u03b1 precede major complications of bone marrow transplantation","volume":"75","author":"Holler E","year":"1990","journal-title":"Blood"},{"key":"e_1_2_1_33_2","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1182\/blood.V82.7.2025.2025","article-title":"A randomized controlled trial of pentoxifylline for the prevention of regimen\u2010related toxicities in patients undergoing allogeneic marrow transplantation","volume":"82","author":"Clift RA","year":"1993","journal-title":"Blood"},{"key":"e_1_2_1_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0268-960X(93)90023-W"}],"container-title":["Medical and Pediatric Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmpo.2950240513","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mpo.2950240513","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,27]],"date-time":"2023-10-27T03:07:49Z","timestamp":1698376069000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mpo.2950240513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,5]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1995,5]]}},"alternative-id":["10.1002\/mpo.2950240513"],"URL":"https:\/\/doi.org\/10.1002\/mpo.2950240513","archive":["Portico"],"relation":{},"ISSN":["0098-1532","1096-911X"],"issn-type":[{"value":"0098-1532","type":"print"},{"value":"1096-911X","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,5]]}}}