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Of these children 96, 11, and 28 suffered from B\u2010progenitor, mature B\u2010cell, and T\u2010cell malignancies, respectively. In two patients initial central nervous system involvement was documented by the presence of lymphoblasts with high CSF cell counts (B+C+ patients); 19 patients had CSF lymphoblasts with normal CSF cell counts (B+C\u2212 patients); the others had no CSF blasts and normal CSF cell counts (B\u2010C\u2010 patients). In B+C\u2212 and B\u2010C\u2010 patients 5\u2010year\u2010leukaemia\u2010free survival was 66 and 70%, respectively (i.e., not significantly different). None of the B+C\u2212 patients experienced a first relapse in the central nervous system. Differences in outcome by comparing with reports of others may be related to the use of dexamethasone instead of prednisone in almost all of our patients. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/mpo.2950250106","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T19:22:21Z","timestamp":1171999341000},"page":"22-27","source":"Crossref","is-referenced-by-count":16,"title":["Significance of lymphoblasts in cerebrospinal fluid in newly diagnosed pediatric acute lymphoblastic malignancies with bone marrow involvement: Possible benefit of dexamethasone"],"prefix":"10.1002","volume":"25","author":[{"given":"Henk","family":"van den Berg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond","family":"Vet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmy","family":"den 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