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This paper describes the design and sampling strategies, instruments, and experimental procedures applied in a study programme aimed to examine military deployment\u2010related mental health and disorders (prevalence and trajectories) and to identify vulnerability and risk factors (e.g. age, gender, type of mission, rank, and duration of deployment and a wide range of neurobiological, psychological, social, and behavioural factors).<\/jats:p><jats:p>The study comprised two components. The first component, a cross\u2010sectional study, included 1483 deployed and 889 non\u2010deployed German soldiers (response rate, 93%) who served during the 2009 International Security Assistance Force (ISAF) mission. A standardized diagnostic instrument (Composite International Diagnostic Interview, CIDI) coupled with established questionnaires was administered to detect and diagnose PTSD and a broad spectrum of mental disorders and mental health problems. The second component, a prospective\u2010longitudinal study, included 621 soldiers examined before (2011) and after return (2012) from the ISAF mission. In addition to the CIDI and questionnaires, several experimental behavioural tests and biological markers were implemented to probe for incident mental disorders, mental health problems and risk factors. Our methods are expected to provide greater precision than previous studies for estimating the risk for incident deployment\u2010related and non\u2010deployment\u2010related disorders and their risk factors. We expect the findings to advance our understanding of a wide spectrum of adverse mental health outcomes beyond PTSD. Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/mpr.1356","type":"journal-article","created":{"date-parts":[[2012,5,18]],"date-time":"2012-05-18T04:05:03Z","timestamp":1337313903000},"page":"98-116","source":"Crossref","is-referenced-by-count":32,"title":["Prevalence, incidence and determinants of PTSD and other mental disorders: design and methods of the PID\u2010PTSD+<sup>3<\/sup> study"],"prefix":"10.1002","volume":"21","author":[{"given":"Hans\u2010Ulrich","family":"Wittchen","sequence":"first","affiliation":[{"name":"Institute of Clinical Psychology and Psychotherapy and Centre of Epidemiology and Longitudinal Studies (CELOS) Technische Universit\u00e4t Dresden  Dresden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Sch\u00f6nfeld","sequence":"additional","affiliation":[{"name":"Institute of Clinical Psychology and Psychotherapy and Centre of Epidemiology and Longitudinal Studies (CELOS) Technische 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