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The factors determining this unfavourable outcome remain unknown.<\/jats:p><jats:p>The Netherlands Obsessive Compulsive Disorder Association (NOCDA) study is a multicentre naturalistic cohort study of the biological, psychological and social determinants of chronicity in a clinical sample. Recruitment of OCD patients took place in mental health organizations. Its design is a six\u2010year longitudinal cohort study among a representative clinical sample of 419 OCD patients. All five measurements within this six\u2010year period involved validated semi\u2010structured interviews and self\u2010report questionnaires which gathered information on the severity of OCD and its co\u2010morbidity as well as information on general wellbeing, quality of life, daily activities, medical consumption and key psychological and social factors. The baseline measurements also include DNA and blood sampling and data on demographic and personality variables. The current paper presents the design and rationale of the study, as well as data on baseline sample characteristics. Demographic characteristics and co\u2010morbidity ratings in the NOCDA sample closely resemble other OCD study samples. Lifetime co\u2010morbid Axis I disorders are present in the majority of OCD patients, with high current and lifetime co\u2010morbidity ratings for affective disorders (23.4% and 63.7%, respectively) and anxiety disorders other than OCD (36% current and 46.5% lifetime). <jats:italic>Copyright \u00a9 2012 John Wiley &amp; Sons, Ltd<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/mpr.1372","type":"journal-article","created":{"date-parts":[[2012,11,12]],"date-time":"2012-11-12T16:13:02Z","timestamp":1352736782000},"page":"273-285","source":"Crossref","is-referenced-by-count":49,"title":["The Netherlands Obsessive Compulsive Disorder Association (NOCDA) study: design and rationale of a longitudinal naturalistic study of the course of OCD and clinical characteristics of the sample at baseline"],"prefix":"10.1002","volume":"21","author":[{"given":"Josien","family":"Schuurmans","sequence":"first","affiliation":[{"name":"Department of Clinical Psychology and EMGO\u2009+\u2009Institute VU University 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