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A receiver\u2010operating characteristic analysis was performed on randomly selected patients to determine the YMRS optimal severity threshold with CGI\u2010BP mania score\u2009\u2265\u2009\u201cMarkedly ill\u201d defining severity. The MCSD (clinically meaningful change in score relative to one point difference in CGI\u2010BP mania for outcome measures) of YMRS, was assessed with a linear regression on baseline data.<\/jats:p><jats:p>At baseline, YMRS mean score was 26.4 (\u00b19.9), CGI\u2010BP mania mean score was 4.8 (\u00b11.0) and 61.7% of patients had a score\u2009\u2265\u20095. The optimal YMRS severity threshold of 25 (positive predictive value [PPV]\u2009=\u200983.0%; negative predictive value [NPV]\u2009=\u200966.0%) was determined. In this cohort, a YMRS score of 20 (typical cutoff for RCTs inclusion criteria) corresponds to a PPV of 74.6% and to a NPV of 77.6%, meaning that the majority of patients included would be classified as severely ill. The YMRS minimal clinically significant difference was 6.6 points. Copyright \u00a9 2013 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/mpr.1379","type":"journal-article","created":{"date-parts":[[2013,3,23]],"date-time":"2013-03-23T06:23:05Z","timestamp":1364019785000},"page":"46-58","source":"Crossref","is-referenced-by-count":120,"title":["Young Mania Rating Scale: how to interpret the numbers? 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