{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:02:23Z","timestamp":1753869743827,"version":"3.41.2"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T00:00:00Z","timestamp":1529971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009655","name":"Sunovion","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009655","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Methods Psych Res"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Site\u2010independent ratings surveillance assessed ratings reliability in a clinical trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Inter\u2010rater reliability was assessed at the screen visit in a 6\u2010week, double\u2010blind, placebo\u2010controlled study of lurasidone for the treatment of major depressive disorder (MDD) with subthreshold hypomanic (\u201cmixed\u201d) symptoms (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">clinicaltrials.gov<\/jats:ext-link> NCT01421134). Site\u2010based Montgomery\u2010Asberg Depression Rating Scale (MADRS) and Young Mania Rating Scale (YMRS) interviews were paired with 184 site\u2010independent ratings derived from audio\u2010digital recordings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The paired MADRS and YMRS scores were highly correlated (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.708 and 0.885, respectively) and generated minimal scoring discordance. The surveillance program identified 14 MADRS scores (7.6% of this sample) that were below the study entry criterion (MADRS \u226526) and resulted in screen failure.<\/jats:p><jats:p>When present, paired scoring discordance was associated with symptom severity, interview length, interview quality, and the level of patient cooperation.<\/jats:p><jats:p>Higher severity scores (MADRS \u226540 and YMRS \u226515) were associated with greater paired scoring discordance. Further, MADRS scores &lt;30 and short MADRS interviews conducted in \u226412\u00a0min revealed significantly more pairs of discordant outliers (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.04 and 0.009, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The findings suggest that MDD patients with mixed features can be reliably assessed, that paired site\u2010based and site\u2010independent assessments were generally concordant, and that ratings surveillance may reinforce ratings precision.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mpr.1729","type":"journal-article","created":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T07:24:40Z","timestamp":1529997880000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Ratings surveillance and reliability in a study of major depressive disorder with subthreshold hypomania (mixed features)"],"prefix":"10.1002","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1054-5197","authenticated-orcid":false,"given":"Steven D.","family":"Targum","sequence":"first","affiliation":[{"name":"Bracket Global LLC  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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