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We assessed impairment (Sheehan Disability Scales and number of days out of role [DOR] in the past 30\u00a0days) and seven 12\u2010month DSM\u2010IV disorders. We defined six multivariate mental disorder classes using latent class analysis (LCA). We simulated population attributable risk proportions (PARPs) of impairment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Highest prevalence of role impairment was highest among the 1.9% of students in the LCA class with very high comorbidity and bipolar disorder (C1): 78.3% of them had severe role impairment (vs. 20.8%, total sample). Impairment was lower in two other comorbid classes (C2 and C3) and successively lower in the rest. A similar monotonic pattern was found for DOR. Both LCA classes and some mental disorders (major depression and panic, in particular) were significant predictors of role impairment. PARP analyses suggest that eliminating all mental disorders might reduce severe role impairment by 64.6% and DOR by 44.3%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Comorbid mental disorders account for a substantial part of role impairment in college students.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mpr.1750","type":"journal-article","created":{"date-parts":[[2018,11,7]],"date-time":"2018-11-07T07:03:18Z","timestamp":1541574198000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["The role impairment associated with mental disorder risk profiles in the WHO World Mental Health International College Student Initiative"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8627-9636","authenticated-orcid":false,"given":"Jordi","family":"Alonso","sequence":"first","affiliation":[{"name":"Health Services Research Group, IMIM (Hospital del Mar Medical 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