{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T07:59:20Z","timestamp":1762761560449,"version":"3.41.2"},"reference-count":58,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T00:00:00Z","timestamp":1558569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"CENC Neuroimaging Core","award":["1I0RX001062","PT120517","I01RX002174"],"award-info":[{"award-number":["1I0RX001062","PT120517","I01RX002174"]}]},{"name":"U.S. Department of Veterans Affairs Chronic Effects of Neurotrauma Consortium","award":["W81XWH-13-2-0095"],"award-info":[{"award-number":["W81XWH-13-2-0095"]}]},{"name":"U.S. Army Medical Research and Material Command"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Methods Psych Res"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The chronic effects of neurotrauma consortium (CENC) observational study is a multisite investigation designed to examine the long\u2010term longitudinal effects of mild traumatic brain injury (mTBI). All participants in this initial CENC cohort had a history of deployment in Operation Enduring Freedom (Afghanistan), Operation Iraqi Freedom (Iraq), and\/or their follow\u2010on conflicts (Operation Freedom's Sentinel). All participants undergo extensive medical, neuropsychological, and neuroimaging assessments and either meet criteria for any lifetime mTBI or not. These assessments are integrated into six CENC core studies\u2014<jats:italic>Biorepository<\/jats:italic>, <jats:italic>Biostatistics<\/jats:italic>, <jats:italic>Data and Study Management<\/jats:italic>, <jats:italic>Neuroimaging<\/jats:italic>, and <jats:italic>Neuropathology<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The current study outlines the quantitative neuroimaging methods managed by the <jats:italic>Neuroimaging Core<\/jats:italic> using FreeSurfer automated software for image quantification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At this writing, 319 participants from the CENC observational study have completed all baseline assessments including the imaging protocol and tertiary data quality assurance procedures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions\/Discussion<\/jats:title><jats:p>The preliminary findings of this initial cohort are reported to describe how the Neuroimaging Core manages neuroimaging <jats:italic>quantification<\/jats:italic> for CENC studies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mpr.1781","type":"journal-article","created":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T06:47:23Z","timestamp":1558680443000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Structural neuroimaging in mild traumatic brain injury: A chronic effects of neurotrauma consortium study"],"prefix":"10.1002","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3031-3919","authenticated-orcid":false,"given":"Erin D.","family":"Bigler","sequence":"first","affiliation":[{"name":"Psychology Department and Neuroscience Center Brigham Young University  Provo Utah"},{"name":"Department of Neurology University of Utah  Salt Lake City Utah"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tracy 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