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We hypothesize that <jats:italic>a priori<\/jats:italic> prediction of treatment (non\u2010)response is possible in a second, independent sample based on multimodal markers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One\u2010session virtual reality exposure treatment (VRET) with patients with spider phobia was conducted on two sites. Clinical, neuroimaging, and genetic data were assessed at baseline, post\u2010treatment and after 6 months. The primary and secondary outcomes defining treatment response are as follows: 30% reduction regarding the individual score in the Spider Phobia Questionnaire and 50% reduction regarding the individual distance in the behavioral avoidance test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:italic>N<\/jats:italic> = 204 patients have been included (<jats:italic>n<\/jats:italic> = 100 in W\u00fcrzburg, <jats:italic>n<\/jats:italic> = 104 in M\u00fcnster). 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