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Following theory and initial research indicating the promise of mindful yoga interventions (MYIs), this study examines mindful yoga as a treatment of MDD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods\/Design<\/jats:title><jats:p>This randomized controlled trial uses a sample of young females (18\u201334\u2009years) to examine the efficacy and cost\u2010effectiveness of a 9\u2010week manualized MYI added to treatment as usual (TAU) versus TAU alone. Primary outcome measures consist of clinician\u2010administered (Hamilton Depression Rating Scale) and self\u2010report (Depression\u2010Anxiety\u2010Stress Scales) measures of depression. Underlying mechanisms will be examined, including rumination, negative self\u2010evaluation, intolerance of uncertainty, interoceptive awareness, and dispositional mindfulness. Assessments were conducted at preintervention and will be conducted at postintervention, 6\u2010, and 12\u2010month follow up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The baseline sample consists of 171 females (88 were randomized into the MYI), reporting a baseline <jats:italic>M<\/jats:italic><jats:sub>age<\/jats:sub> = 25.08\u2009years (<jats:italic>SD<\/jats:italic><jats:sub>age<\/jats:sub> = 4.64), <jats:italic>M<\/jats:italic><jats:sub>Hamilton\u2010depression<\/jats:sub> = 18.39 (<jats:italic>SD<\/jats:italic><jats:sub>Hamilton<\/jats:sub> = 6.00), and a <jats:italic>M<\/jats:italic><jats:sub>DASS\u2010depression<\/jats:sub> = 21.02 (<jats:italic>SD<\/jats:italic><jats:sub>DASS<\/jats:sub> = 9.36).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This trial will provide important information regarding the benefits of adding yoga\u2010based interventions to TAU for young women with MDD and the mechanisms through which such benefits may occur.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mpr.1820","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T05:39:01Z","timestamp":1582004341000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["A mindful yoga intervention for young women with major depressive disorder: Design and baseline sample characteristics of a randomized controlled trial"],"prefix":"10.1002","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7221-2585","authenticated-orcid":false,"given":"Nina K.","family":"Vollbehr","sequence":"first","affiliation":[{"name":"Lentis Psychiatric Institute Center for Integrative Psychiatry  Groningen Netherlands"},{"name":"Department of Clinical Psychology and Experimental Psychopathology University of Groningen  Groningen Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.J. 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